Xiaomin Xu
Sichuan University
IntegrinIn vitroIn vivoChemotherapyDrugDoxorubicinCancer researchBreast cancerMedicineDistribution (pharmacology)
Publications 2
#1Yuai Li (Sichuan University)
#2Lan Yang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Size expansion can effectively improve tumor accumulation of nanocarriers where precise control is required. A dual-responsive nanocarrier stimulated by both endogenous pH and exogenous heat stimuli can change its size. Herein, a nanoparticle composed of poly(N,N-diethyl acrylamide) (PDEAA) and poly(2-(diisopropylamino) ethyl methacrylate) (PDPA) is developed. The antitumor drug celastrol (CLT) and the photosensitizer indocyanine green (ICG) are then loaded in it to form CIPP. ICG generates heat...
#1Bingjie Zhou (Sichuan University)H-Index: 2
#2Min Li (Sichuan University)
Last. Shiqi Huang (Sichuan University)H-Index: 4
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Breast cancer was the leading cause of newly diagnosed cases of tumors in 2020, ranking as the second highest cause of female death. Chemotherapy remains the conventional treatment of choice for breast tumors in most clinical cases. However, it is often accompanied by a poor prognosis and severe side effects, resulting from an insufficient accumulation of the drug at tumor sites and an unsystematic distribution of the drug across the body. Inspired by the fact that breast tumor cells overexpress...