Nicole C. Nowak
Northwestern University
PathophysiologyCutaneous innervationSensory nerveType 2 diabetesDiabetic foot ulcerPeripheral neuropathyWound healingPathogenesisBioinformaticsMedicine
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#1Nicole C. Nowak (NU: Northwestern University)
#2Daniela M. Menichella (NU: Northwestern University)H-Index: 13
Last. Amy S. Paller (NU: Northwestern University)H-Index: 36
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Type 2 diabetes (T2D) is associated with several potential comorbidities, among them impaired wound healing, chronic ulcerations, and the requirement for lower extremity amputation. Disease-associated abnormal cellular responses, infection, immunological and microvascular dysfunction, and peripheral neuropathy are implicated in the pathogenesis of the wound healing impairment and the diabetic foot ulcer. The skin houses a dense network of sensory nerve afferents and nerve-derived modulators, whi...
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