Lan Yang
Sichuan University
Therapeutic effectDruggabilityProdrugTransporterProinflammatory cytokineBioavailabilityChemistryIntegrinIn vitroIn vivoChemotherapyRheumatoid arthritisInflammatory bowel diseaseBlockadeDrugAutoimmunityDexamethasonePathogenesisDoxorubicinPopulationToxicityCancer researchBreast cancerMedicinePharmacologyDistribution (pharmacology)
Publications 4
#1Yuai Li (Sichuan University)
#2Lan Yang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Size expansion can effectively improve tumor accumulation of nanocarriers where precise control is required. A dual-responsive nanocarrier stimulated by both endogenous pH and exogenous heat stimuli can change its size. Herein, a nanoparticle composed of poly(N,N-diethyl acrylamide) (PDEAA) and poly(2-(diisopropylamino) ethyl methacrylate) (PDPA) is developed. The antitumor drug celastrol (CLT) and the photosensitizer indocyanine green (ICG) are then loaded in it to form CIPP. ICG generates heat...
Abstract null null Current clinical agents for autoimmunity disorders treatment often cause substantial adverse effects and safety concerns, owing to non-specific immune modulation. Due to the prominent contribution of effector T cells in pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and preferential location of co-stimulatory receptor-ligand pair OX40-OX40L at the inflamed sites, selectively targeting autoaggressive T cells by blockade OX40-OX40L, might represe...
#1Bingjie Zhou (Sichuan University)H-Index: 2
#2Min Li (Sichuan University)
Last. Shiqi Huang (Sichuan University)H-Index: 4
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Breast cancer was the leading cause of newly diagnosed cases of tumors in 2020, ranking as the second highest cause of female death. Chemotherapy remains the conventional treatment of choice for breast tumors in most clinical cases. However, it is often accompanied by a poor prognosis and severe side effects, resulting from an insufficient accumulation of the drug at tumor sites and an unsystematic distribution of the drug across the body. Inspired by the fact that breast tumor cells overexpress...
#1Honglin Xiang (Sichuan University)
#2Qiang Zhang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Currently, ischemic stroke is the leading cause of disability and death worldwide, and the performance of corresponding drugs is often unsatisfactory owing to the complex pathological processes and the impediment of the blood-brain barrier (BBB). Here, we employed various tertiary amino groups, including different linear, cyclic, and bimolecular drug structures, to modify 3-n-butylphthalide (NBP), a natural product used for ischemic stroke treatment, which has poor bioavailability, to generate a...