Maxime Gestin
Royal Institute of Technology
SortaseChemistryEndopeptidaseSortase ADimerAffibody moleculeThermostabilityExopeptidaseThermal stabilityStereochemistry
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Natural backbone-cyclized proteins have an increased thermostability and resistance towards proteases, characteristics that have sparked interest in head-to-tail cyclization as a method to stability-enhance proteins used in diagnostics and therapeutic applications, for example. In this proof-of principle study, we have produced and investigated a head-to-tail cyclized and HER2-specific ZHER2:342 Affibody dimer. The sortase A-mediated cyclization reaction is highly efficient (>95%) under optimize...
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