Maxime Gestin
Royal Institute of Technology
SortaseChemistryEndopeptidaseSortase ADimerAffibody moleculeThermostabilityExopeptidaseThermal stabilityStereochemistry
Publications 1
#2Anders MyrhammarH-Index: 1
view all 5 authors...
Natural backbone-cyclized proteins have an increased thermostability and resistance towards proteases, characteristics that have sparked interest in head-to-tail cyclization as a method to stability-enhance proteins used in diagnostics and therapeutic applications, for example. In this proof-of principle study, we have produced and investigated a head-to-tail cyclized and HER2-specific ZHER2:342 Affibody dimer. The sortase A-mediated cyclization reaction is highly efficient (>95%) under optimize...
1 CitationsSource