Zhuo Wang
CorrelationBiophysicsInternal medicineCircular dichroismCardiologyInhibitory postsynaptic potentialChemistryAngular gyrusLasso (statistics)Nile redLiquiritigeninTau proteinThioflavinCongo redBioactive compoundNeurotoxicityPrecuneusHeptelidic acidPreventive carePotential candidateNomogramReactive oxygen speciesStrokeBiochemistryReceiver operating characteristicMedicineArea under the curveAmyloid
Publications 3
Abstract Aggregation of tau protein into the form of insoluble amyloid fibrils is linked with Alzheimer's disease. The identification of potential small molecules that can inhibit tau protein from undergoing aggregation has received a great deal of interest, recently. In the present study, the possible inhibitory effects of liquiritigenin as a member of chiral flavanone family on tau amyloid fibrils formation and their resulting neurotoxicity were assessed by different biophysical and cellular a...
Last. Mojtaba Falahati (IAU: Islamic Azad University)H-Index: 23
view all 5 authors...
Abstract Tau is a major component of protein plaques in tauopathies, especially Alzheimer's disease (AD). The purpose of the present study is to explore the inhibitory effects of heptelidic acid as a bioactive compound from fungus T. koningii on tau fibrillization and associated neurotoxicity. The influences of various concentrations of heptelidic acid on tau fibrillization and underlying neurotoxicity were explored by assessment of the biophysical (ThT/Nile red fluorescence, CR absorbance, CD, ...
Objective: To explore the clinical value of a risk prediction model of post-stroke cognitive impairment (PSCI) based on proton magnetic resonance spectroscopy (1H-MRS).Methods:A retrospective analysis was conducted on 376 stroke patients hospitalized between March 2016 and March 2019. Their relevant clinical baseline data were collected at admission. After the patients' condition was stabilized, 1H-MRS was performed to detect the related indices of the bilateral prefrontal lobe, thalamus, basal ...