Toshihiko Tashima
TranscytosisOral administrationSmall intestineDrugGastrointestinal tractIntestinal epitheliumMembrane permeabilityMonoclonal antibodyMedicinePharmacology
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Oral administration of medications is highly preferred in healthcare owing to its simplicity and convenience; however, problems of drug membrane permeability can arise with any administration method in drug discovery and development. In particular, commonly used monoclonal antibody (mAb) drugs are directly injected through intravenous or subcutaneous routes across physical barriers such as the cell membrane, including the epithelium and endothelium. However, intravenous administration has disadv...
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