Preston Carey
Matrix metalloproteinaseProteasesExtracellular matrixTumor microenvironmentMetastasisOvarian tumorAngiogenesisOvarian cancerCancer researchBiology
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Proteases play a crucial role in the progression and metastasis of ovarian cancer. Pericellular protein degradation and fragmentation along with remodeling of the extracellular matrix (ECM) is accomplished by numerous proteases that are present in the ovarian tumor microenvironment. Several proteolytic processes have been linked to cancer progression, particularly those facilitated by the matrix metalloproteinase (MMP) family. These proteases have been linked to enhanced migratory ability, extra...
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