Yongdae Yoon
Yonsei University
CD90Adipose tissueTumor necrosis factor alphaChemistryApoptosisMesenchymal stem cellIn vitroIn vivoInterferonCell-penetrating peptideHepatocyte growth factorLiver diseaseProstaglandin E2MyoDGliomaHoming (hematopoietic)Liver transplantationContext (language use)ImmunosuppressionProstaglandinStem cellTransplantationLiver functionSecretionCancer researchTransfectionBioinformaticsMedicineInterleukinCell biology
Publications 3
#1Young Un Choi (Yonsei University)H-Index: 4
#2Yongdae Yoon (Yonsei University)
Last. Young Woo Eom (Yonsei University)H-Index: 17
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Background/aim null Mesenchymal stem cell-based tumor therapy is still limited due to the insufficient secretion of effectors and discrepancies between their in vitro and in vivo efficacy. We investigated whether genetically engineered adipose tissue-derived mesenchymal stem cells (ASCs) overexpressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) had inhibitory effects on H460 tumor growth both in vitro and in an H460 xenograft model. null Materials and methods null Geneticall...
#1Jaesik Shin (Yonsei University)
#2Soon Koo Baik (Yonsei University)H-Index: 42
Last. Young Woo Eom (Yonsei University)H-Index: 17
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BACKGROUND/AIM Genetic manipulation of stem cells using non-viral vectors is still limited due to low transfection efficiency. We investigated whether the DNA-binding cell-permeation peptides (CPP) can enhance the transfection efficiency of non-viral vectors in adipose tissue-derived mesenchymal stem cells (ASCs) and whether ASCs over-expressing TRAIL through CPP can inhibit the growth of glioma U251MG cells in vitro and in vivo. MATERIALS AND METHODS ASCs were genetically engineered to over-exp...
PURPOSE OF REVIEW Liver transplantation is the gold standard for the treatment of end-stage liver disease. However, a shortage of donor organs, high cost, and surgical complications limit the use of this treatment. Cellular therapies using hepatocytes, hematopoietic stem cells, bone marrow mononuclear cells, and mesenchymal stem cells (MSCs) are being investigated as alternative treatments to liver transplantation. The purpose of this review is to describe studies using MSC transplantation for l...