Ya-Ting Wang
Beijing University of Chinese Medicine
Quality of lifeInternal medicineDownregulation and upregulationNeurotrophic factorsRandomized controlled trialNeuroscienceTraditional Chinese medicineSystematic reviewNeurotransmissionAutophagyNeuroprotectionPINK1PaeoniflorinParkinPaeonia lactifloraDepression (differential diagnoses)AntidepressantMitophagyMEDLINEParkinson's diseaseGuidelineLRRK2GlutamatergicSubstantia nigraMitochondrionPsychiatric DiseaseGlycine bindingMonoaminergicMetabotropic glutamate receptorGlutamate receptorMedicineBiologyMeta-analysisSynaptic plasticityPharmacology
3Publications
2H-index
2Citations
Publications 4
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#1Ya-Ting Wang (Beijing University of Chinese Medicine)H-Index: 2
#2Xiao-Le Wang (Beijing University of Chinese Medicine)H-Index: 2
Last. Yi Zhang (Beijing University of Chinese Medicine)H-Index: 10
view all 6 authors...
Abstract null null Major depressive disorder (MDD) is severely prevalent, and conventional monoaminergic antidepressants gradually exhibit low therapeutic efficiency, especially for patients with treatment-resistant depression. A neuroplasticity hypothesis is an emerging advancement in the mechanism of depression, mainly expressed in the glutamate system, e.g., glutamate receptors and signaling. Dysfunctional glutamatergic neurotransmission is currently considered to be closely associated with t...
2 CitationsSource
#1Xiao-Le Wang (Beijing University of Chinese Medicine)H-Index: 2
#2Si-Tong Feng (Beijing University of Chinese Medicine)H-Index: 4
Last. Yi Zhang (Beijing University of Chinese Medicine)H-Index: 10
view all 6 authors...
Abstract null null Background null Depression, as a prevalent and debilitating psychiatric disease, severely decreases the life quality of individuals and brings heavy burdens to the whole society. Currently, some antidepressants are applied in the treatment of severe depressive symptoms, while there are still some undesirable drawbacks. Paeoniflorin is a monoterpenoid glycoside that was firstly extracted from Paeonia lactiflora Pall, a traditional Chinese herb that is widely used in the Chinese...
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#1Si-Tong Feng (Beijing University of Chinese Medicine)H-Index: 4
#2Xiao-Le Wang (Beijing University of Chinese Medicine)H-Index: 2
Last. Yi Zhang (Beijing University of Chinese Medicine)H-Index: 15
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Depression is a common neuropsychiatric symptom of Parkinson's disease (PD), resulting in a lower quality of life and cognitive impairment in PD patients. Traditional Chinese medicine (TCM) formulas have been widely used in neurodegenerative disease and neuropsychic disorders to improve life quality of patients in ethnomedicine. TCM formulas combined with selective serotonin reuptake inhibitors (SSRIs) also have a positive effect on depressed PD compared with SSRIs as reported by several clinica...
2 CitationsSource
#1Xiao-Le Wang (Beijing University of Chinese Medicine)H-Index: 2
#2Si-Tong Feng (Beijing University of Chinese Medicine)H-Index: 4
Last. Yi Zhang (Beijing University of Chinese Medicine)H-Index: 10
view all 8 authors...
Parkinson's disease (PD) is a severe neurodegenerative disorder caused by the progressive loss of dopaminergic neurons in the substantia nigra and affects millions of people. Currently, mitochondrial dysfunction is considered as a central role in the pathogenesis of both sporadic and familial forms of PD. Mitophagy, a process that selectively targets damaged or redundant mitochondria to the lysosome for elimination via the autophagy devices, is crucial in preserving mitochondrial health. So far,...
1 CitationsSource