Carlos Sosa-Marrero
University of Rennes
Internal medicineRadiologyMagnetic resonance imagingOncologyLogistic regressionMitotic catastropheIn silicoExternal beam radiotherapyProstateBiochemical recurrenceRadiomicsProstate cancerAngiogenesisTumor responseRadiation therapyMedicine
Publications 2
#2Pierre FontaineH-Index: 3
Last. Oscar AcostaH-Index: 21
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In prostate cancer radiotherapy, biochemical recurrence has been traditionally predicted using radiomics approaches with however limited performance. The purpose of this work was to use a mechanistic in silico model of tumor growth and response to irradiation to obtain better predictions. A cohort of 76 patients with localized prostate adenocarcinoma having undergone external beam radiotherapy was used. Analogous digital tissues were built from pre-treatment MRI. The prescribed irradiation proto...
OBJECTIVE Purposes of this work were i) to develop an in silico model of tumor response to radiotherapy, ii) to perform an exhaustive sensitivity analysis in order to iii) propose a simplified version and iv) to predict biochemical recurrence with both the comprehensive and the reduced model. METHODS A multiscale computational model of tumor response to radiotherapy was developed. It integrated the following radiobiological mechanisms: oxygenation, including hypoxic death; division of tumor cell...