Pin Li
University of California, San Diego
Endothelial stem cellMitogen-activated protein kinaseUnfolded protein responseVEGF receptorsChemistryMacular degenerationVascular endothelial growth factorGlycosylationHeparinNeovascularizationAngiogenesisRetinalProtein glycosylationClinical trialBioinformaticsMetabolismMedicineCell biology
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1H-index
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Publications 2
Newest
#1Hong Xin (UCSD: University of California, San Diego)H-Index: 2
#2Nilima Biswas (UCSD: University of California, San Diego)H-Index: 16
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 7 authors...
Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of patients have been treated with these drugs worldwide. However, in real-life clinical settings, many patients do not experience the same degree of benefit observed in clinical trials, in part because they receive fewe...
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#1Zhong Cuiling (UCSD: University of California, San Diego)H-Index: 2
#2Pin Li (UCSD: University of California, San Diego)H-Index: 1
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 10 authors...
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation in ECs and induces significant changes in N-glycan and O-glycan profiles. We further demonstrate that ManN and two N-glycosylation inhibitors stimulate EC proliferation via both JNK activation and th...
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