Manon Leclerc
Laval University
Beta (finance)Insulin receptorEndocrinologyGenetically modified mouseLipogenesisGut–brain axisNeuroprotectionTetrahydrobiopterinSteatosisOxysterolBlood–brain barrierFatty liverDiseaseInsulinNeuropathologyLiver functionDiabetes mellitusMedicineBeta oxidationAmyloid
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Publications 3
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The scope of evidence on the neuroprotective impact of natural products has been greatly extended in recent years. However, a key question that remains to be answered is whether natural products act directly on targets located in the central nervous system (CNS), or whether they act indirectly through other mechanisms in the periphery. While molecules utilized for brain diseases are typically bestowed with a capacity to cross the blood–brain barrier, it has been recently uncovered that periphera...
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Background Alzheimer's disease (AD) is a multifactorial disease, implying that multi-target treatments may be necessary to effectively cure AD. Tetrahydrobiopterin (BH4) is an enzymatic cofactor required for the synthesis of monoamines and nitric oxide that also exerts antioxidant and anti-inflammatory effects. Despite its crucial role in the CNS, the potential of BH4 as a treatment in AD has never been scrutinized. Objective Here, we investigated whether BH4 peripheral administration improves c...
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#1Manon Leclerc (Laval University)
#2Philippe Bourassa (Laval University)H-Index: 6
Last. Frédéric Calon (Laval University)H-Index: 55
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