Marie Vincenti
Mayo Clinic
Cell therapyInternal medicineCardiologyUmbilical cordVentricleHypoplastic left heart syndromeFractional area changeCavopulmonary AnastomosisAutologous cellMedicineEjection fraction
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Preservation of right ventricle function (RV) is a key to favorable outcome in Hypoplastic Left Heart Syndrome (HLHS), but methods to preserve or improve RV function are limited. Our goal was to assess the clinical and functional impact of autologous umbilical cord blood-derived mononuclear cells (UCB-MNC) therapy when given to patients with HLHS at Stage II surgery. UCB-MNC patients were enrolled prospectively in a phase I, FDA monitored trial as previously described (Burkhart et al., 2019). Ma...
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