Tania Kümpfel
Charité
Internal medicineEndocrinologySurgeryPathologyMagnetic resonance imagingAntibodyPediatricsImmunologyDiseaseCentral nervous system diseaseAutoimmunityMultiple sclerosisExpanded Disability Status ScaleNatalizumabNeuromyelitis opticaIn patientMutationHormoneMedicineBiologyImmune systemGastroenterology
81Publications
28H-index
3,492Citations
Publications 77
Newest
Objectives null To evaluate the long-term effects of natalizumab (NTZ) on different features of intrathecal immunoglobulin (Ig) synthesis in patients with multiple sclerosis (MS) and to quantify the expression of α4-integrin in stages of B-cell maturation. null Methods null We combined a cross-sectional (49 NTZ-treated MS patients, mean treatment duration 5.1 years, and 47 untreated MS patients) and a longitudinal study (33 patients with MS before and during NTZ, mean treatment duration: 4.8 yea...
Source
#1Matin MortazaviH-Index: 3
Last. Birgit Ertl-Wagner (U of T: University of Toronto)H-Index: 41
view all 9 authors...
Abstract null null Multiple genetic and non-heritable factors have been linked to the risk of multiple sclerosis (MS). These factors seem to contribute to disease pathogenesis before the onset of clinical symptoms, as suggested by incidental MRI evidence of subclinical MS neuropathology in individuals without clinical symptoms. Individuals with high familial risk for MS, such as first-degree relatives of patients with MS, can be studied by MRI to characterize the neuropathology during a subclini...
Source
Objective null To analyze serum immunoglobulin G (IgG) antibodies to major isoforms of myelin oligodendrocyte glycoprotein (MOG-alpha 1-3 and beta 1-3) in patients with inflammatory demyelinating diseases. null Methods null Retrospective case-control study using 378 serum samples from patients with multiple sclerosis (MS), patients with non-MS demyelinating disease, and healthy controls with MOG alpha-1-IgG positive (n = 202) or negative serostatus (n = 176). Samples were analyzed for their reac...
Source
#1Hannah PellkoferH-Index: 7
#1Hannah PellkoferH-Index: 17
Last. Tania KümpfelH-Index: 28
view all 2 authors...
Multiple Sklerose und Neuromyelitis-optica-Spektrum-Erkrankungen sind autoimmun-entzundliche Erkrankungen des zentralen Nervensystems, die zu vielfaltigen neurologischen Beschwerden und Schmerzsyndromen fuhren konnen, sowohl akut im Rahmen eines Erkrankungsschubs als auch chronisch, wobei Letzteres die Lebensqualitat teils erheblich reduziert. Die Atiologie der Schmerzen ist sehr heterogen, deren rasche differenzialdiagnostische Zuordnung jedoch entscheidend, um differenzierte Therapiestrategien...
Source
#1Ilya AyzenbergH-Index: 19
#2Daniel RichterH-Index: 4
Last. Ingo KleiterH-Index: 35
view all 26 authors...
Objectives To evaluate prevalence, clinical characteristics, and predictors of pain, depression, and their impact on the quality of life (QoL) in a large neuromyelitis optica spectrum disorder (NMOSD) cohort. Methods We included 166 patients with aquaporin-4–seropositive NMOSD from 13 tertiary referral centers. Patients received questionnaires on demographic and clinical characteristics, PainDetect, short form of Brief Pain Inventory, Beck Depression Inventory–II, and Short Form 36 Health Survey...
Source
Objective In this observational study, we investigated the impact of genetic factors at the immunoglobulin heavy chain constant locus on chromosome 14 and the major histocompatibility complex region on intrathecal immunoglobulin G, A, and M levels as well as on B cells and plasmablasts in the CSF and blood of patients with multiple sclerosis (MS). Methods Using regression analyses, we tested genetic variants on chromosome 14 and imputed human leukocyte antigen (HLA) alleles for associations with...
2 CitationsSource
#1Simone Mader (LMU: Ludwig Maximilian University of Munich)H-Index: 23
#2Tania KümpfelH-Index: 28
Last. Edgar MeinlH-Index: 65
view all 3 authors...
PURPOSE OF REVIEW: This review summarizes recent insights into the pathogenesis and therapeutic options for patients with MOG- or AQP4-antibodies. RECENT FINDINGS: Although AQP4-IgG are linked to NMOSD, MOG-IgG-associated diseases (MOGAD) include a broader clinical spectrum of autoimmune brain disease. Details of membrane assembly of AQP4-IgG required for complement activation have been uncovered. Affinity-purified MOG-IgG from patients were shown to be pathogenic by induction of demyelination w...
15 CitationsSource
#1Sinah Engel (University of Mainz)H-Index: 4
#2Christiane Graetz (University of Bern)H-Index: 11
Last. Felix LuessiH-Index: 21
view all 30 authors...
Objective To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS). Methods This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (e4) and rs7412 (e2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was eva...
3 CitationsSource
#1Mitja MitrovicH-Index: 11
Last. Julia Y MescheriakovaH-Index: 10
view all 50 authors...
(Cell 175, 1679–1687.e1–e7; November 29, 2018) It has come to our attention that in preparing the final version of this article, the authors inadvertently misspelled the last name of author Charlotte E. Teunissen as “Charlotte E. Theunissen.” This error has been corrected in the article online. In the Editorial Note (Cell 178, 262, June 27, 2019), the editors refer to the original version of the published manuscript. That version contained a misspelled name, and as that has now been corrected, w...
#1Eduardo BeltránH-Index: 9
#2Lisa Ann GerdesH-Index: 11
Last. Klaus DornmairH-Index: 38
view all 11 authors...
Multiple sclerosis (MS) is a disabling disease of the CNS. Inflammatory features of MS include lymphocyte accumulations in the CNS and cerebrospinal fluid (CSF). The preclinical events leading to established MS are still enigmatic. Here we compared gene expression patterns of CSF cells from MS-discordant monozygotic twin pairs. Six "healthy" co-twins, who carry a maximal familial risk for developing MS, showed subclinical neuroinflammation (SCNI) with small MRI lesions. Four of these subjects ha...
30 CitationsSource