Ela Novianti
Kagoshima University
Internal medicineEndocrinologyHippocampal formationAMPA receptorAstrocyteNeuronStreptozotocinMicrogliaDiet-induced obeseCorticosteroneHippocampusCognitive declineSaturated fatCX3CR1NMDA receptorMedicineTropomyosin receptor kinase B
2Publications
1H-index
0Citations
Publications 4
Newest
#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Ela Novianti (Kadai: Kagoshima University)H-Index: 1
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 7 authors...
The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucros...
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#1Ela Novianti (LIPI: Indonesian Institute of Sciences)H-Index: 1
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 5 authors...
Abstract null null Atractylenolide-III (AIII), a sesquiterpene compound isolated from the rhizome of Atractylodes macrocephala, has been reported to have anti-inflammatory effects in the peripheral organs. However, its effects on brain inflammation remain elusive. The present study investigated the effects of AIII on the response to lipopolysaccharide (LPS) in mouse microglia and clarified the underlying mechanism. In this study, treatment of MG6 cells with AIII (100 μM) significantly decreased ...
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#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akihiro Asakawa (Kadai: Kagoshima University)H-Index: 30
view all 6 authors...
Introduction A diet high in saturated fat is well known to affect neuronal function and contribute to cognitive decline in experimental animals and humans. Fractalkine released from neurons acts on its receptor, CX3C chemokine receptor 1 (CX3CR1), in the microglia to regulate several brain functions. The present study addressed whether fractalkine-CX3CR1 signaling in the brain, especially the hippocampus, contributes to the cognitive deficits observed in diet-induced obese (DIO) mice. Research d...
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#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akihiro Asakawa (Kadai: Kagoshima University)H-Index: 30
view all 6 authors...
Patients with diabetes mellitus are predisposed to cognitive impairment. Fractalkine-CX3CR1 in the brain signaling represents a primary neuron-microglia inter-regulatory system for several brain functions including learning and memory processes. The present study addressed whether fractalkine-CX3CR1 signaling in the hippocampus contributes to the cognitive deficits observed in streptozotocin (STZ)-treated mice. Our results showed that STZ-treated mice exhibited significant cognitive deficits in ...
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