Yan Peng
Nanchang University
Genetic enhancementCyclin DInternal medicineDownregulation and upregulationDifferential centrifugationEndocrinologyBiomedical engineeringSurgerymicroRNARegeneration (biology)ChemistryMicroarrayMaterials scienceMesenchymal stem cellCyclin D1In vitroSensory nerveSubstance PNerve fiberVascular endothelial growth factorStreptozotocinBone marrowWound healingType I collagenStem cellPopulationMicroRNA Expression ProfilePoor wound healingCell cycleA431 cellsReal-time polymerase chain reactionTissue engineeringCancer researchTransfectionDiabetes mellitusMolecular medicineMedicineCell cultureBiologyEpidermis (botany)Cell biology
Publications 5
#1Fei-bin Zhu (NCU: Nanchang University)H-Index: 1
#2Xiang-jing FangH-Index: 1
Last. De-ming Liu (NCU: Nanchang University)H-Index: 4
view all 9 authors...
Exogenous substance P accelerates wound healing in diabetes, but the mechanism remains poorly understood. Here, we established a rat model by intraperitoneally injecting streptozotocin. Four wounds (1.8 cm diameter) were drilled using a self-made punch onto the back, bilateral to the vertebral column, and then treated using amniotic membrane with epidermal stem cells and/or substance P around and in the middle of the wounds. With the combined treatment the wound-healing rate was 100% at 14 days....
5 CitationsSource
#1Zhifang Song (NCU: Nanchang University)H-Index: 1
#2Dewu Liu (NCU: Nanchang University)H-Index: 6
Last. Pu Ning (NCU: Nanchang University)H-Index: 3
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Abstract The aim of the current study was to analyze the differential microRNA (miRNA) expression profiles of human epidermal stem cells (ESCs) and differentiated keratinocytes. Enzyme digestion was used in combination with rapid adhesion to collagen IV to isolate primary human ESCs and differentiated keratinocytes, from which total RNA was extracted. Fluorescence labeling, microarray hybridization and differential expression analyses were performed. Reverse transcription quantitative polymerase...
4 CitationsSource
#1Qingling Zhong (NCU: Nanchang University)H-Index: 4
#2Fanrong Liu (NCU: Nanchang University)H-Index: 6
Last. Xiangrong Zhang (NCU: Nanchang University)H-Index: 2
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: The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms involved in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction of β-catenin and its downstream target in ESCs, cyclin D1, lead to poor wound healing in diabetes mellitus (DM). We found that, compared to the controls, the ESCs of diabetic rat...
41 CitationsSource
#1Xiang Rong Zhang (NCU: Nanchang University)
#2De Wu Liu (NCU: Nanchang University)
Last. Yan Peng (NCU: Nanchang University)H-Index: 3
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The development of skin tissue engineering provides a noninvasive method for skin restoration. Unfortunately, the lack of a vascular plexus leads to greater time for vascularization compared with native skin autografts and contributes to graft failure. Our purpose was to construct tissue-engineered skin with VEGF- modified human bone marrow mesenchymal stem cells (hMSCs) as well as acellular dermal matrix(ADM) in vitro , Thus by increased vascular endothelial growth factor expression, which coul...
#1Dewu Liu (NCU: Nanchang University)H-Index: 3
#2Xiangrong Zhang (NCU: Nanchang University)H-Index: 2
Last. Yan Peng (NCU: Nanchang University)H-Index: 3
view all 4 authors...
Vascular endothelial growth factor 165 (VEGF165) is one of the most prominent vascular growth factors that has the potential to accelerate wound healing by promoting the regeneration of capillary vasculature. However, the short biological half-live of growth factors may impose severe restraints on their clinical applications. Here, we investigate the feasibility and safety of human bone marrow derived mesenchymal stem cells (MSCs) transfected with VEGF165 gene so as to provide a new method for c...