Richou Han
Chinese Academy of Sciences
HemolymphGeneAcute toxicityAmes testHost (biology)MyceliumCellGene expressionTranscriptomeMedian lethal doseVEGF receptorsLarvaLepidoptera genitaliaPhytochemicalBuddingMetabolomicsEntomopathogenic fungusApis ceranaDefensinCecropinInsectChinese hamsterHoney beeFlavobacteriumDeformed wing virusHepialidaeOphiocordyceps sinensisCordycepsVarroa destructorSerratia proteamaculansHypoxia (medical)ThitarodesOphiocordycipitaceaeFungusCarnobacteriumCLTCGhost mothHypocrealesAngiogenesisBlastosporeOphiocordycepsVarroaAscomycotaPreferenceSignal PathwaysDopaminergic synapseGlutamatergic synapsePaecilomyces hepialiCell invasionHyphal growthRespiratory chainMicronucleusMicronucleus testSenescenceGeneticsTraditional medicineBotanyBiologyImmune systemMicrobiologyHyphaZoologyChorioallantoic membranePharmacology
8Publications
2H-index
11Citations
Publications 10
Newest
#1Hailin Long (CAS: Chinese Academy of Sciences)H-Index: 1
#2Xuehong Qiu (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Richou Han (CAS: Chinese Academy of Sciences)H-Index: 2
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Abstract Ethnopharmacological relevance Hypoxia will cause an increase in the rate of fatigue and aging. Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus complex in the Qinghai-Tibet Plateau, has long been used to ameliorate human conditions associated with aging and senescence, it is principally applied to treat fatigue, night sweating and other symptoms related to aging, and it may play the anti-aging and anti-fatigue effect by improving the body's hypoxia tolera...
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Last. Richou HanH-Index: 2
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#1Rui Tang (CAS: Chinese Academy of Sciences)H-Index: 8
Last. Richou Han (CAS: Chinese Academy of Sciences)H-Index: 2
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Cordyceps, a parasitic complex of the fungus Ophiocordyceps sinensis (Berk.) (Hypocreales: Ophiocordycipitaceae) and the ghost moth Thitarodes (Lepidoptera: Hepialidae), is a historical ethnopharmacological commodity in China. Recently, artificial cultivation of Chinese cordyceps has been established to supplement the dwindling natural resources. However, much is unknown between the natural and cultivated products in terms of nutritional aspect, which may provide essential information for qualit...
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#1Zhongchen Rao (CAS: Chinese Academy of Sciences)H-Index: 3
#2Li Cao (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Richou Han (CAS: Chinese Academy of Sciences)H-Index: 2
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Aggressive behavior in animals is important for survival and reproduction. It is well studied in adult insects, such as flies, ants, honey bees, and crickets. However, the larvae of Lepidopteran insects are also aggressive, studies of which are still lacking. Here, RNA-seq was used to generate a high-quality database for the aggressive behavior of Thitarodes xiaojinensis toward conspecifics and heterospecifics. Although there was similar aggressive behavior between the conspecific group and hete...
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#1Balachandar Balakrishnan (CAS: Chinese Academy of Sciences)
#1B. Balakrishnan (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Richou Han (CAS: Chinese Academy of Sciences)
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The honey bee is a significant crop pollinator and key model insect for understanding social behavior, disease transmission, and development. The ectoparasitic Varroa destructor mite put threats on the honey bee industry. A Varroa toxic protein (VTP) from the saliva of Varroa mites contributes to the toxicity toward Apis cerana and the deformed wing virus elevation in Apis mellifera. However, the immune response and hemolymph microbiota of honey bee species after the injection of recombinant VTP...
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#1Guiqing LiuH-Index: 4
Last. Richou HanH-Index: 2
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By employing a culture-dependent and -independent 16S rRNA and ITS gene high-throughput sequencing analyses, comprehensive information was obtained on the gut bacterial and fungal communities in the ghost moth larvae of three different geographic locations from high-altitude on Tibet plateau and from low-altitude laboratory. Twenty-six culturable bacterial species belonging to 21 genera and 14 fungal species belonging to 12 genera were identified from six populations by culture-dependent method....
1 CitationsSource
#1Hailin LongH-Index: 1
#2Xuehong QiuH-Index: 4
Last. Richou HanH-Index: 2
view all 6 authors...
Abstract Ethnopharmacological relevance The Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus complex in the Qinghai-Tibet Plateau, is one of the most valuable traditional Chinese medicines and health food for ameliorating conditions associated with aging and for treating fatigue, night sweats, hyperglycemia, hyperlipidemia, respiratory, renal and liver diseases, and hyposexuality. The natural Chinese cordyceps resource is rare due to its harsh growing environment, ...
4 CitationsSource
#1Hua Wu (UGent: Ghent University)H-Index: 2
#2Zhongchen RaoH-Index: 3
Last. Richou Han (CAS: Chinese Academy of Sciences)
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The Chinese cordyceps is a unique and valuable parasitic complex of Thitarodes/Hepialus ghost moths and the Ophiocordyceps sinensis fungus for medicine and health foods from the Tibetan Plateau. During artificial cultivation of Chinese cordyceps, the induction of blastospores into hyphae is a prerequisite for mummification of the infected Thitarodes larvae. To explore the microbial involvement in the induction of mycelia-blastospore transition, the microbiota of the hemolymph and gut from Thitar...
4 CitationsSource
#1Guiqing LiuH-Index: 4
#2Li CaoH-Index: 6
Last. Richou HanH-Index: 2
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The entomopathogenic fungus Ophiocordyceps sinensis is one of the best known and most precious medicines and health food in China. The blastospores-hyphae (dimorphism) transition of this fungus in host hemolymph is critical for the virulence and the mummification of host larvae. To regulate this transition, the effects of inoculum density and fifteen chemicals including fungal nutrients, fungal metabolites, quorum-sensing molecules (QSMs) and insect hormones on the dimorphism in O. sinensis were...
2 CitationsSource
#1Zhongchen RaoH-Index: 3
#2Li CaoH-Index: 6
Last. Richou HanH-Index: 2
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Thitarodes armoricanus is a medicinal and economically important Lepidopteran insect species. The larvae infected by Paecilomyces hepiali survive no more than four days, while those infected by Ophiocordyceps sinensis can survive for several months before mummification. This provides a valuable comparative system to study interactions between an insect host and different pathogenic fungi. By using the T. armoricanus genome, a time-course transcriptome analysis of the whole larvae without guts wa...
5 CitationsSource