Yvonne L. Rimmer
Cambridge University Hospitals NHS Foundation Trust
Acute toxicityInternal medicineRadiologySurgeryOncologyRandomized controlled trialRadiation treatment planningClinical endpointBleomycinProstateHead and neck cancerChemotherapyGerm cell tumorsAndrogen deprivation therapyEtoposideCisplatinTolerabilityContouringProstate cancerBladder cancerService (business)Radiation oncologistHypofractionated Radiation TherapyToxicityNuclear medicineMuscle invasiveSkill setsHealth professionalsElderly populationPhases of clinical researchCancer researchRadiation therapyClinical trialData setMedicine
26Publications
7H-index
237Citations
Publications 21
Newest
#1Nikita Sushentsev (University of Cambridge)H-Index: 5
#2Yvonne L. Rimmer (University of Cambridge)H-Index: 7
Last. Tristan Barrett (University of Cambridge)H-Index: 36
view all 3 authors...
Giant multilocular prostatic cystadenoma (GMPC) is a rare benign pelvic mass for which complete surgical resection is an accepted treatment of choice. This report presents the first case of complete resolution of GMPC following a 3-year course of luteinising hormone-releasing hormone agonist alongside external beam radiotherapy for the concurrent treatment of unfavorable intermediate-risk prostate cancer. In addition to illustrating the imaging features of the effect of androgen deprivation ther...
Source
#1Robert Huddart (ICR: Institute of Cancer Research)H-Index: 83
#2Shaista Hafeez (ICR: Institute of Cancer Research)H-Index: 13
Last. Hybrid InvestigatorsH-Index: 1
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Purpose Hypofractionated radiation therapy can be used to treat patients with muscle-invasive bladder cancer unable to have radical therapy. Toxicity is a key concern, but adaptive plan-of the day (POD) image-guided radiation therapy delivery could improve outcomes by minimizing the volume of normal tissue irradiated. The HYBRID trial assessed the multicenter implementation, safety, and efficacy of this strategy. Methods HYBRID is a Phase II randomized trial that was conducted at 14 UK hospitals...
8 CitationsSource
#1Ozan OktayH-Index: 23
#2Jay NanavatiH-Index: 4
Last. Aditya V. NoriH-Index: 32
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IMPORTANCE: Personalized radiotherapy planning depends on high-quality delineation of target tumors and surrounding organs at risk (OARs). This process puts additional time burdens on oncologists and introduces variability among both experts and institutions. OBJECTIVE: To explore clinically acceptable auto-contouring solutions that can be integrated into existing workflows and used in different domains of radiotherapy. DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study used a mul...
#1Ozan Oktay (Microsoft)H-Index: 23
#2Jay Nanavati (Microsoft)H-Index: 4
Last. Yvonne L. Rimmer (Cambridge University Hospitals NHS Foundation Trust)H-Index: 7
view all 15 authors...
Importance Personalized radiotherapy planning depends on high-quality delineation of target tumors and surrounding organs at risk (OARs). This process puts additional time burdens on oncologists and introduces variability among both experts and institutions. Objective To explore clinically acceptable autocontouring solutions that can be integrated into existing workflows and used in different domains of radiotherapy. Design, Setting, and Participants This quality improvement study used a multice...
8 CitationsSource
#1David P. Dearnaley (The Royal Marsden NHS Foundation Trust)H-Index: 108
#2Clare Griffin (ICR: Institute of Cancer Research)H-Index: 15
Last. Emma Hall (ICR: Institute of Cancer Research)H-Index: 57
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325Background: CHHiP is a non-inferiority trial to determine efficacy and safety of hypofractionated radiotherapy for localised prostate cancer (PCa). Five year results indicated that moderate hypo...
2 CitationsSource
#1Robert Huddart (The Royal Marsden NHS Foundation Trust)H-Index: 83
#2Rebecca Lewis (ICR: Institute of Cancer Research)H-Index: 12
Last. Emma Hall (ICR: Institute of Cancer Research)H-Index: 57
view all 19 authors...
503Background: Level 1 evidence exists for the use of both neoadjuvant chemotherapy (NAC) and concomitant radiosensitization (CRS) to improve outcomes in patients receiving radical radiotherapy (RT...
1 CitationsSource
#1Douglas Brand (ICR: Institute of Cancer Research)H-Index: 5
#2Alison Tree (ICR: Institute of Cancer Research)H-Index: 20
Last. N OommenH-Index: 1
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Summary Background Localised prostate cancer is commonly treated with external-beam radiotherapy. Moderate hypofractionation has been shown to be non-inferior to conventional fractionation. Ultra-hypofractionated stereotactic body radiotherapy would allow shorter treatment courses but could increase acute toxicity compared with conventionally fractionated or moderately hypofractionated radiotherapy. We report the acute toxicity findings from a randomised trial of standard-of-care conventionally ...
119 CitationsSource
#1A. HuntH-Index: 4
#2A. ChanH-Index: 1
Last. Shaista HafeezH-Index: 13
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2 CitationsSource
#1Nikita SushentsevH-Index: 5
#2H. Martin (Cambridge University Hospitals NHS Foundation Trust)H-Index: 1
Last. Tristan Barrett (University of Cambridge)H-Index: 17
view all 4 authors...
Purpose To evaluate the added value of diffusion-weighted imaging (DWI) to T2-weighted imaging (T2WI) for improved identification of pelvic lymph nodes (LN) by radiation oncologists.
2 CitationsSource
#1David P. Dearnaley (ICR: Institute of Cancer Research)H-Index: 108
#2Clare Griffin (ICR: Institute of Cancer Research)H-Index: 15
Last. Emma Hall (ICR: Institute of Cancer Research)H-Index: 57
view all 18 authors...
Purpose To establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely deliverable at multiple centers. Methods and Materials In this phase 2 noncomparative multicenter trial, 124 patients with locally advanced, high-risk prostate cancer were randomized between prostate-only IMRT (PO) (74 Gy/37 fractions) and prostate and pelvic lymph node IMRT (PP 74 Gy/37 fractions to prostate, 60 Gy/37 fractions to pelvis). The ...
16 CitationsSource