Li Jing
Shanghai Jiao Tong University
CytotoxicityBiophysicsCell migrationSolubilityBioavailabilityChemistryApoptosisIn vitroIn vivoCell-penetrating peptidePolyethylene glycolOral administrationHyaluronic acidHeparinIC50MetastasisNicotinamideDrug deliveryDrugPLGADoxorubicinReactive oxygen speciesCancer researchFlow cytometryProtein kinase BPI3K/AKT/mTOR pathwayPharmacology
12Publications
5H-index
100Citations
Publications 12
Newest
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 119
#1Jun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 9 authors...
Triple-negative breast cancer (TNBC) is characterized by a high metastatic rate, which can seriously threaten women's health. ROS play an important role in tumor development and metastasis. Excessive ROS can induce tumor cell apoptosis and inhibit tumor cell metastasis. This study investigated Fenton-reaction-stimulative nanoparticles (P@P/H NPs) containing ROS-responsive molecular switches for antitumor metastasis by amplifying the ROS and activating the cascade biological reaction of ROS in tu...
5 CitationsSource
#1Tiantian Zuo (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Jing Li (SJTU: Shanghai Jiao Tong University)H-Index: 35
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 7 authors...
As the principal reason for the inducement of high mortality, tumor metastasis is regulated by different pathways owing to its complexity and multistep process. In order to inhibit the proliferation and metastasis of human breast cancer simultaneously, controlling the codelivery of chemotherapeutics and pathway inhibitors precisely has been considered as a high-potential strategy to accurately eliminate tumor metastasis. In this study, polymer PLGA-p-PEI-DA was synthesised and automatically asse...
3 CitationsSource
#1Yu Luo (Tongji University)H-Index: 1
#2Yuehua Li (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Li Wu (SJTU: Shanghai Jiao Tong University)H-Index: 30
view all 6 authors...
Regarded as the most promising technology for an early and precise detection of pancreatic cancer, a sensitive nanoprobe has been developed to enhance the accumulation of contrast agent at the tumor site. Hyaluronic acid (HA)-mediated multifunctional Fe3O4 nanoparticles (NPs) were used to target pancreatic cancer cells because on their cytomembrane they overexpress CD44, a receptor protein that has a high affinity to HA. The formation of HA-mediated multifunctional Fe3O4 nanoparticles began with...
4 CitationsSource
#1Li Wu (Fudan University)H-Index: 2
#2Li Jing (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Xiaolin Wang (Fudan University)H-Index: 2
view all 5 authors...
Purpose To investigate the value of using diffusion-weighted imaging (DWI) and intravoxel incoherent motion DWI (IVIM-DWI) to assess the chemotherapy response of pancreatic cancer in an orthotopic mouse model.
2 CitationsSource
#1Xiao Liang (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Shu-Mao Xu (SJTU: Shanghai Jiao Tong University)H-Index: 14
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 1
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Tumor cells are vulnerable to reactive oxygen species (ROS). However, it is still a challenge to induce ROS efficiently in tumor cells. In this study, cascade amplifiers of intracellular ROS based on charge-reversible mitochondria-targeted ZnO-TPP@D/H nanorods (NRs) were first developed for breast cancer therapy. The core–shell ZnO-TPP@D/H NR with a particle size of 179.60 ± 5.67 nm was composed of a core of a ZnO NR, an inner shell of triphenyl phosphonium (TPP), and an outer shell of heparin. ...
10 CitationsSource
#1Yifan Yang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Yunzhi Yin (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 7 authors...
Oral delivery is considered the preferred route of administration due to its convenience and favorable compliance. Here, docetaxel (DTX) loaded polylactic-co-glycolic acid (PLGA) nanoparticles, coated with polyethyleneimine–folic acid (PEI-FA) and polyethyleneimine–borneol (PEI-BO), were designed to enhance oral absorption (FA/BO-PLGA-NPs). The FA/BO-PLGA-NPs were spherical and smooth with an average size of (137.0 ± 2.1) nm. Encapsulation efficiency (EE%) and drug loading (DL%) were (80.3 ± 1.8...
8 CitationsSource
#1Li Jing (SJTU: Shanghai Jiao Tong University)H-Index: 5
#1Jing Li (SJTU: Shanghai Jiao Tong University)H-Index: 27
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 8 authors...
Abstract In this study, heparin and polyethyleneimine–folic acid modified graphene oxide was designed and synthesized as a dual-targeting biomaterial to load doxorubicin (DOX@GPFH) with high loading capacity for enhanced cellular uptake. GDC0941, a phosphatidylinositide 3-kinase/Akt phosphorylation inhibitor, was selected to enhance anti-metastasis effect of DOX@GPFH via down-regulating expression of matrix metalloproteinase. Modified with heparin, the stability of DOX@GPFH was significantly enh...
18 CitationsSource
#1Yunzhi Yin (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Yiyue Wang (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 6 authors...
Abstract Docetaxel (DTX) is one kind of well-known anticancer drugs against tumors. GDC0941 was used to inhibit PI3K/Akt signal pathway and improve anti-tumor activity. PLGA-PEG-R7 (poly lactic-co-glycolic acid polyethylene glycol bending with cell penetrating peptide R7)/poly sulfadimethoxine-Folate nanoparticles (R7/PSD-Fol NPs) were made to load DTX and GDC0941 simultaneously. In vitro, the release capacity of DTX and GDC0941 inside nanoparticles was determined and both drugs could release fr...
Source
#1Li Jing (SJTU: Shanghai Jiao Tong University)H-Index: 5
#1Jing Li (SJTU: Shanghai Jiao Tong University)H-Index: 27
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 7 authors...
Abstract Metastasis impedes the successful chemotherapy for breast cancer. In this study, an Akt inhibitor (quercetin, Qu) was co-delivered with a chemotherapeutic agent (docetaxel, DTX) by using hyaluronic acid (HA)-modified nanoparticles (NPs) as vectors to block metastasis. Dual DTX/Qu-loaded HA/polylactic-co-glycolic acid–polyethyleneimine NPs (PP-HA/NPs) were prepared through a modified emulsion solvent evaporation technique. The particle size of PP-HA/NPs with narrow polydispersity was 209...
42 CitationsSource
#1Yiyue Wang (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Li Jing (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Qi Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 6 authors...
The polylactic-co-glycolic acid polyethylene glycol conjugated with cell penetrating peptide R7 (PLGA–PEG-R7)/polysulfadimethoxine-folate nanoparticles loaded with docetaxel (DTX) and GDC0941 (R7/PSD-Fol NPs) were prepared to overcome multidrug resistance (MDR) and enhance the antitumor activity. First, polysulfadimethoxine-folate was synthesized to construct the R7/PSD-Fol NPs. The R7/PSD-Fol NPs were prepared with the abilities of effective entrapment and drug loading. Due to the pH-sensitive ...
9 CitationsSource