Qianru Tang
Nantong University
Downregulation and upregulationMitogen-activated protein kinaseCell migrationmicroRNAGene knockdownChemistryHsp90Lung cancermir-137MetastasisKRASProgrammed cell deathReactive oxygen speciesCancer researchColorectal cancerCell growthEpithelial–mesenchymal transitionPI3K/AKT/mTOR pathwayBiology
Publications 2
#1Xiaoling Ding (Nantong University)H-Index: 4
#2Jie Zhang (Nantong University)H-Index: 10
Last. Xiaorong Zhou (Nantong University)H-Index: 5
view all 5 authors...
In colorectal cancer (CRC), miR-137-3p downregulation is associated with disease progression, but the mechanism is not fully understood. KDM1A, also known as LSD1, is upregulated in various cancer and promotes tumor metastasis. Interestingly, miR-137-3p is downregulated by hypoxia, which plays critical roles in tumor metastasis, and KDM1A is a miR-137-3p target gene in brain tumors. To study if CRC metastasis is regulated by a hypoxia/miR-137-3p/KDM1A axis and if the epithelial–mesenchymal trans...
#1Mangze Hu (Nantong University)H-Index: 1
#2Yu Zhao (Nantong University)H-Index: 11
Last. Xiaorong Zhou (Nantong University)H-Index: 1
view all 7 authors...
Metabolic alterations are well documented in various cancers. Non-small cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramm...
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