Sheida Shahraki
GeneCytotoxicityCancerBiophysicsInternal medicinePeroxisome proliferator-activated receptor gammaDrug carrierGenotypeOncologyCase-control studyDynamic light scatteringCellPolymorphism (computer science)Single-nucleotide polymorphismCytotoxic T cellOdds ratioAlleleBioavailabilityChemistryMicroemulsionApoptosisIn vitroAutophagyEcological studyMoietyValproic AcidHeLaAntioxidantPyrimidineMEDLINEDoxorubicinPopulationToxicityQuantitative assessmentGenotypingActive siteBreast cancerGeneticsBiochemistryCarcinogenesisCell growthSignal transductionMedicineIntracellularCell cultureBiologyMechanism (biology)Meta-analysisCell biologyCancer cellPharmacology
6Publications
1H-index
4Citations
Publications 6
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#1Saman SargaziH-Index: 4
#2Sheida ShahrakiH-Index: 1
Last. Ramin SaravaniH-Index: 10
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Abstract Due to their unique pharmacological characteristics, methylxanthines are known as therapeutic agents in a fascinating range of medicinal scopes. In this report, we aimed to examine some biological effects of previously synthesized 8-alkylmercaptocaffeine derivatives. Cytotoxic and antioxidative activity of 8-alkylmercaptocaffeine derivatives were measured in malignant A549, MCF7, and C152 cell lines. Assessment of cGMP levels and caspase-3 activity were carried out using a colorimetric ...
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#1Habib GhaznaviH-Index: 26
#2Milad Shirvaliloo (Tabriz University of Medical Sciences)H-Index: 3
Last. Roghayeh SheervalilouH-Index: 12
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Autophagy is a perplexing mechanism through which a living cell can free itself of excess cytoplasmic components by means of certain membranous vesicles or lysosomes filled with degrading enzymes. Upon exposure to external insult or internal stimuli, the cell might opt to activate such pathway through which it can gain control over the maintenance of intracellular components. Despite such appropriateness, autophagy, might also be considered a frailty for the cell, as it has been said to have a r...
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#1Abbas RahdarH-Index: 17
#2Saman SargaziH-Index: 4
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Encapsulation of the chemotherapy agents within colloidal systems usually improves drug efficiency and decreases its toxicity. In this study, lignin (LGN) (the second most abundant biopolymer next to cellulose on earth) was employed to prepare novel doxorubicin (DOX)-loaded oil-in-water (O/W) microemulsions with the aim of enhancing the bioavailability of DOX. The droplet size of DOX-loaded microemulsion was obtained as ≈ 7.5 nm by dynamic light scattering (DLS) analysis. The entrapment efficien...
3 CitationsSource
Last. Ebrahim Eskandari (UBC: University of British Columbia)
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OBJECTIVE Growing evidence suggests that IL-1β -511C>T, as a functional variant, affects the risk of developing breast cancer (BC); however, the results have not been conclusive. This meta-analysis was conducted to estimate the link between this variant and BC risk. METHODS We retrieved available publications on IL-1β -511C>T polymorphism by conducting a comprehensive literature search on the Web of Science, MEDLINE, PubMed, Scopus, and Google scholar databases (last search on February 25, 2020)...
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#1Saman SargaziH-Index: 4
Last. Mansoor ShakibaH-Index: 2
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Objective: Schizophrenia (SCZ) is a common psychiatric disorder characterized by a complex mode of inheritance. Peroxisome proliferator-activated receptor-γ (PPARG) mainly regulates lipid and glucose metabolisms while it is constitutively expressed in rat primary microglial cultures. This preliminary study was aimed to investigate the relationship of two polymorphisms in the PPARG gene, rs1801282 C/G, and rs3856806 C/T, to the risk of SCZ in the southeast Iranian population. Method: A total of 3...
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