Yuqing Lin
Guangzhou University of Chinese Medicine
PhosphorylationCaspase 1PyroptosisChemistryInflammationArthritisWedelolactoneInflammasomeLactate dehydrogenaseMitochondrial ROSGallic acidLipopolysaccharideSecretionCell biologyPharmacology
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#1Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 1
#2Tianyu Luo (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 1
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Gallic acid is an active phenolic acid widely distributed in plants, and there is compelling evidence to prove its anti-inflammatory effects. NLRP3 inflammasome dysregulation is closely linked to many inflammatory diseases. However, how gallic acid affects the NLRP3 inflammasome remains unclear. Therefore, in the present study, we investigated the mechanisms underlying the effects of gallic acid on the NLRP3 inflammasome and pyroptosis, as well as its effect on gouty arthritis in mice. The resul...
5 CitationsSource
#1Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 2
#2Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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OBJECTIVES Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti-inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on investigating the mechanism of wedelolactone on NLRP3 inflammasome in macrophages and its influence on MSU-induced inflammation. MATERIALS AND METHODS BMDM, J774A.1 and PMA-differentiated THP-1 macrophages were primed with LPS and then stimulated with ATP or nigericin or MSU crystal ...
9 CitationsSource