Stephen P. Wright
University of Toronto
Internal medicineEndocrinologyCardiac outputPulmonary wedge pressureAdaptationCardiologyHemodynamicsPhysical therapyPolyunsaturated fatty acidCardiac catheterizationHeart failureVentriclePulmonary hypertensionPulmonary arteryAthletesPopulationLight ExerciseTransplantationRight heart catheterizationIn patientPhysiologyDiastoleMedicineBlood pressureBiology
67Publications
12H-index
416Citations
Publications 38
Newest
#1Lauren J Frazee (TU: Temple University)H-Index: 1
#2Joanna L. Rifkin (U of T: University of Toronto)H-Index: 3
Last. Rachel B. Spigler (TU: Temple University)H-Index: 12
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The evolutionary transition from outcross-fertilization to self-fertilization is one of the most common in angiosperms and is often associated with a parallel shift in floral morphological and developmental traits, such as reduced flower size and pollen to ovule ratios, known as the 'selfing syndrome'. How these convergent phenotypes arise, the extent to which they are shaped by selection, and the nature of their underlying genetic basis are unsettled questions in evolutionary biology. The genus...
1 CitationsSource
#1Tony G. Dawkins (Cardiff Metropolitan University)H-Index: 5
#2Bryony A. Curry (Cardiff Metropolitan University)H-Index: 2
Last. Mike Stembridge (Cardiff Metropolitan University)H-Index: 15
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Background: Structural remodeling of the right ventricle (RV) is widely documented in athletes. However, functional adaptation, including RV pressure generation and systolic free-wall longitudinal ...
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#1Julia M. Kreiner (U of T: University of Toronto)H-Index: 6
#2George Sandler (U of T: University of Toronto)H-Index: 5
Last. Stephen P. Wright (U of T: University of Toronto)H-Index: 12
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Causal mutations and their frequency in nature are well-characterized for herbicide resistance. However, we still lack understanding of the extent of parallelism in the mutational origin of target-site resistance (TSR), the role of standing variation and gene flow in the spread of TSR variants, and allelic interactions that mediate their selective advantage. We addressed these questions with genomic data from 18 agricultural populations of Amaranthus tuberculatus, which we show to have undergone...
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#1Felipe Homem Valle (UHN: University Health Network)H-Index: 7
#1Felipe H Valle (St. Michael's Hospital)
Last. Susanna Mak (UHN: University Health Network)H-Index: 20
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The use of exercise right heart catheterisation for the assessment of cardiovascular diseases has regained attention recently. Understanding physiologic haemodynamic exercise responses is key for the identification of abnormal haemodynamic patterns. Exercise total pulmonary resistance >3 Wood units identifies a deranged haemodynamic response and when total pulmonary resistance exceeds 3 Wood units, an exercise pulmonary artery wedge pressures/cardiac output slope >2 mmHg/l/min indicates the pres...
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#1Julia M. Kreiner (U of T: University of Toronto)H-Index: 6
#2Patrick M Tranel (UIUC: University of Illinois at Urbana–Champaign)H-Index: 1
Last. Stephen P. Wright (U of T: University of Toronto)H-Index: 12
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Much of what we know about the genetic basis of herbicide resistance has come from detailed investigations of monogenic adaptation at known target-sites, despite the increasingly recognized importance of polygenic resistance. Little work has been done to characterize the broader genomic basis of herbicide resistance, including the number and distribution of genes involved, their effect sizes, allele frequencies, and signatures of selection. In this work, we implemented genome-wide association (G...
3 CitationsSource
#1Felipe Homem ValleH-Index: 7
#2Sam EsfandiariH-Index: 8
Last. Susanna MakH-Index: 20
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The contemporary population of patients with pulmonary arterial hypertension (PAH) are older, with high prevalence of cardiovascular risk factors [1], and potentially at risk for left ventricular diastolic dysfunction [2]. Accordingly, the effect of exercise or volume expansion may elicit augmented increases in pulmonary artery wedge pressure (PAWP) [3, 4], in addition to abnormal behavior of pulmonary artery (PA) pressures. Footnotes This manuscript has recently been accepted for publication in...
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#1Stephen P. Wright (UHN: University Health Network)H-Index: 12
#2Leah A. Groves (UWO: University of Western Ontario)H-Index: 2
Last. Susanna Mak (UHN: University Health Network)
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BACKGROUND The objectives of this study were to describe right ventricular-pulmonary arterial elastance coupling hemodynamic phenotypes and their frequency in patients with advanced heart failure and to evaluate the association of elastance-based indices with all-cause mortality, cardiac transplantation, and left ventricular assist device therapy. METHODS This study included 175 patients with heart failure undergoing right heart catheterization to evaluate candidacy for advanced therapies and 21...
6 CitationsSource
#1Stephen P. WrightH-Index: 12
#2Leah A. GrovesH-Index: 2
Last. Susanna MakH-Index: 9
view all 6 authors...
Source
#1Felipe Homem Valle (UHN: University Health Network)H-Index: 7
#2Sam Esfandiari (UHN: University Health Network)H-Index: 8
Last. Susanna Mak (UHN: University Health Network)H-Index: 20
view all 6 authors...
Purpose Provocative testing during right heart catheterization (RHC) is gaining increasing acceptance to evaluate cardiac and pulmonary vascular contributions to dyspnea. For this purpose, the use of cycle ergometry at measured work rates has been recommended as a physiologically relevant and sensitive stressor. Methods The program was initiated in 07/2016. After standard diagnostic RHC, patients were transferred to a cycle ergometer and hemodynamics were assessed in up to 2 exercise stages if t...
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