Eric Berens
University of California, San Francisco
ProdrugCytotoxicityCancerBiophysicsProtein domainAvidityCovalent bondEnzymeChemistryTissue microarrayConjugateTumor initiationMetastasisTumor progressionPrimary tumorEnzyme assayCancer researchBreast cancerMedicineCancer cell
3Publications
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#1Kevin J. Metcalf (NU: Northwestern University)H-Index: 5
#2Blaise R. Kimmel (NU: Northwestern University)H-Index: 1
Last. Milan Mrksich (NU: Northwestern University)H-Index: 92
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This paper presents a method to synthetically tune atomically precise megamolecule nanobody-enzyme conjugates for prodrug cancer therapy. Previous efforts to create heterobifunctional protein conjugates suffered from heterogeneity in domain stoichiometry, which in part led to the failure of antibody-enzyme conjugates in clinical trials. We used the megamolecule approach to synthesize anti-HER2 nanobody-cytosine deaminase conjugates with tunable numbers of nanobody and enzyme domains in a single,...
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#1Aamna J. AbbasiH-Index: 1
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#1Zena Werb (UCSF: University of California, San Francisco)H-Index: 179
#2Hugo Gonzalez (UCSF: University of California, San Francisco)H-Index: 4
Last. Eric Berens (UCSF: University of California, San Francisco)H-Index: 1
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Cancer cells within tumors exist in specialized niches in the microenvironment. The tumor cells are heterogeneous and can have properties as divergent as self-renewal, tumor initiation and repopulation potential, dormancy, evasion of cell death, and metastasis. Metastasis is the major cause of poor outcome in breast cancer. The microenvironment is critical for regulating multiple aspects of tumor progression and metastasis. Understanding the processes involved in metastasis is critical for devel...
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