Luigi Ricciardiello
University of Bologna
CancerInternal medicineChromosome instabilityOncologyMolecular biologyVirologyImmunologyEicosapentaenoic acidHelicobacter pyloriAdenomaColonoscopyJC virusMicrosatellite instabilityFamilial adenomatous polyposisPopulationHelicobacter pylori infectionCancer researchColorectal cancerDNA mismatch repairMedicineBiologyGastroenterology
Publications 203
#1Patrick MichlH-Index: 15
#2Matthias Löhr (Karolinska University Hospital)H-Index: 55
Last. Luigi Ricciardiello (UNIBO: University of Bologna)H-Index: 35
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BACKGROUND Pancreatic ductal adenocarcinoma is the deadliest cancer worldwide with a 98% loss-of-life expectancy and a 30% increase in the disability-adjusted life years during the last decade in Europe. The disease cannot be effectively prevented nor being early detected. When diagnosed, 80% of patients have tumors that are in incurable stages, while for those who undergo surgery, 80% of patients will present with local or distant metastasis. Importantly, chemotherapies are far from being effec...
1 CitationsSource
#1Amedeo MontaleH-Index: 3
#2Francesco ButtittaH-Index: 2
Last. Luigi RicciardielloH-Index: 35
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#1Subashini Chandrapalan (Coventry Health Care)H-Index: 2
#2Sofie BoschH-Index: 7
Last. Krishna C. PersaudH-Index: 34
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Abstract Background and Aims The SARS-CoV-2 pandemic had a sudden, dramatic impact on healthcare. In Italy, since the beginning of the pandemic, colorectal cancer (CRC) screening programs have been forcefully suspended. We aimed to evaluate whether screening procedure delays can affect the outcomes of CRC screening. Methods We built a procedural model considering delays in the time to colonoscopy and estimating the effect on mortality due to up-stage migration of patients. The number of expected...
17 CitationsSource
#1Manuele Furnari (UniGe: University of Genoa)H-Index: 22
#2Leonardo Henry Eusebi (UNIBO: University of Bologna)H-Index: 25
Last. Edoardo G. Giannini (UniGe: University of Genoa)H-Index: 57
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COVID-19 pandemic enforced the interruption of routine endoscopic examinations raising the issue of potential delays in the diagnosis of high-risk lesions. We conducted a multicentre study to assess the decrease of GI and pancreato-biliary high-risk lesions detection consequent to the reduction of the endoscopic activity. The lockdown period was compared to the equivalent timeframe of the previous 3 years. Endoscopic procedures decreased by 72.9% (elective 72.4% and urgent 51.3%); the overall ca...
3 CitationsSource
#1Luigi Laghi (University of Parma)H-Index: 4
#2Michela Cameletti (University of Bergamo)H-Index: 14
Last. Luigi Ricciardiello (UNIBO: University of Bologna)H-Index: 35
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#1Subashini Chandrapalan (Coventry Health Care)H-Index: 2
#2Sofie BoschH-Index: 7
Last. Ramesh P. Arasaradnam (University of Leicester)H-Index: 25
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Background Faecal immunochemical test (FIT) is emerging as a valid test to rule-out the presence of colorectal cancer (CRC). However, the accuracy of FIT is dependent on the cut-off applied. An additional low-cost test could improve further detection of CRC. Aims To evaluate the efficacy of combined FIT and volatile organic compounds (VOC) in the detection of CRC within symptomatic populations. Methods Systematic reviews on the diagnostic accuracy of FIT and VOC, for the detection of CRC, were u...
4 CitationsSource
#1Francesca CoppolaH-Index: 10
#2Margherita Mottola (UNIBO: University of Bologna)H-Index: 1
Last. Alessandro Bevilacqua (UNIBO: University of Bologna)H-Index: 22
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Our study aimed to investigate whether radiomics on MRI sequences can differentiate responder (R) and non-responder (NR) patients based on the tumour regression grade (TRG) assigned after surgical resection in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT). Eighty-five patients undergoing primary staging with MRI were retrospectively evaluated, and 40 patients were finally selected. The ROIs were manually outlined in the tumour site on T2w sequences in th...
1 CitationsSource
#1Chiara Alquati (UNIBO: University of Bologna)H-Index: 2
#2Anna Prossomariti (UNIBO: University of Bologna)H-Index: 8
Last. Luigi Ricciardiello (UNIBO: University of Bologna)H-Index: 35
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Colorectal cancer (CRC) develops through a multi-step process characterized by the acquisition of multiple somatic mutations in oncogenes and tumor-suppressor genes, epigenetic alterations and genomic instability. These events lead to the progression from precancerous lesions to advanced carcinomas. This process requires several years in a sporadic setting, while occurring at an early age and or faster in patients affected by hereditary CRC-predisposing syndromes. Since advanced CRC is largely u...
1 CitationsSource
#1Francesca DanesiH-Index: 22
#2Carlo MengucciH-Index: 1
Last. Alessandra BordoniH-Index: 33
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Although lifestyle-based interventions are the most effective to prevent metabolic syndrome (MetS), there is no definitive agreement on which nutritional approach is the best. The aim of the present retrospective analysis was to identify a multivariate model linking energy and macronutrient intake to the clinical features of MetS. Volunteers at risk of MetS (F = 77, M = 80) were recruited in four European centres and finally eligible for analysis. For each subject, the daily energy and nutrient ...