Wen Xu
China Three Gorges University
CancermicroRNALung cancerTumor suppressor geneNasopharyngeal carcinomaMetastasisPancreatic cancerBladder cancerOvarian cancerOncogeneCancer researchColorectal cancerBreast cancerCarcinogenesisLong non-coding RNASignal transductionMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCancer cell
9Publications
2H-index
6Citations
Publications 12
Newest
#1Wen Xu (CTGU: China Three Gorges University)H-Index: 2
#2Bei Wang (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 0 authors...
BACKGROUND Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors. This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors, affirming its value as a target for tumor therapy. METHODS The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized by reviewing PubMed. RESULTS The expression of lncRNA...
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#1Chengyu Hu (CTGU: China Three Gorges University)H-Index: 2
#2Wen Xu (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 7 authors...
Background null Long non-coding RNAs (lncRNAs) has no protein-coding potential due to the lack of an apparent open reading frame. There is growing evidence that lncRNA DGCR5 has a vital regulatory role in human illnesses' pathological development, particularly in the digestive system's carcinogenesis and progression. Abnormal DGCR5 expression affects different cellular functions such as proliferation, aggression, and metastasis. This paper aims to probe into the pathophysiological functions and ...
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#1Bei Wang (CTGU: China Three Gorges University)H-Index: 2
#2Wen Xu (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 7 authors...
BACKGROUND Long non-coding RNAs (lncRNA) have influenced numerous biology processes, which has provoked great interest. Not only that, LncRNA DUXAP8 mediates tumorigenesis by affecting the activity of miRNAs, signaling pathways, and oncogene. METHODS The functions of DUXAP8 have been summarized by reading relevant articles on PubMed. RESULTS lncRNA DUXAP8 acts oncogene in most tumors. The abnormal over-expression is associated with the proliferation, invasion, migration, anti-autophagy of tumors...
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#1Yuxuan Cai (CTGU: China Three Gorges University)H-Index: 1
#2Bei Wang (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
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BACKGROUND Endometrial cancer is the fourth most common malignancy in the female population worldwide. It was estimated that 65,620 new cases and 12,590 subsequent deaths occurred in 2020 in the United States. Patients with type II and advanced endometrial cancer do not respond well to the current treatments. Therefore, endometrial cancer should be better understood in order to develop more effective treatments. OBJECTIVE To provide an overview of genetic, metabolic characteristics, therapeutic ...
1 CitationsSource
#1Bei Wang (CTGU: China Three Gorges University)H-Index: 2
#2Wen Xu (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 7 authors...
BACKGROUND Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to summarize various molecular mechanisms of BCAR4 and demonstrate that the biological functions exerted by BCAR4 are good entry points for therapy. METHODS The molecular mechanism of BCAR4 acting on tumors is summarized by reviewing PubMed. RESULTS The expression of lncRNA BCAR4 is abnormally increased in all kinds of tumors,...
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#1Wen Xu (CTGU: China Three Gorges University)H-Index: 2
#2Mengdan Ding (CTGU: China Three Gorges University)
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
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Many experimental shreds of evidence have shown that lncRNA MALAT1 is related to proliferation ability, invasion and migration ability, autophagy ability, and chemoresistance in gastric cancer. Moreover, MALAT1 is related to metastasis and patient prognosis in gastric cancer. This review aims to reveal the biological functions and specific mechanisms of MALAT1 in gastric cancer. METHODS After a comprehensive and systematic search in PubMed, various molecular mechanisms of MALAT1 in mediating gas...
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#1Wen Xu (CTGU: China Three Gorges University)H-Index: 2
#2Bei Wang (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 7 authors...
BACKGROUND Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers. METHODS Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 media...
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#1Wen Xu (CTGU: China Three Gorges University)H-Index: 2
#2Bei Wang (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 6 authors...
BACKGROUND Long non-coding RNA (lncRNA) with little or no coding ability has shown a variety of biological functions in cancer, including epigenetic regulation, DNA damage, regulation of microRNAs, and participation in signal transduction pathways. LncRNA can be used as an oncogene and tumor suppressor gene through transcriptional regulation in cancer. For example, the over-expressed lncRNA DLEU2 promotes the occurrence of laryngeal cancer, lung cancer, hepatocellular carcinoma, etc. and inhibit...
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#1Chengyu Hu (CTGU: China Three Gorges University)H-Index: 2
#2Kai Liu (CTGU: China Three Gorges University)H-Index: 1
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 6 authors...
BACKGROUND There is increasing evidence that lncRNA, a type of transcript which is over 200 nucleotides in length may serve as oncogenes or suppressor genes are implicated in the pathophysiology of human diseases. In particular, tumorigenesis and progress are closely correlated with its abnormal expression. In addition, it may become a promising target for many oncology biotherapies. Abnormal DLX6-AS1 expression affects different cellular processes such as proliferation, aggression and metastasi...
3 CitationsSource
#1Bei Wang (CTGU: China Three Gorges University)H-Index: 2
#2Wen Xu (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
view all 6 authors...
Background CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors. Methods The relationship between CASC15 and tumors was analyzed by searching references, and summarizes the specific pathophysiological mechanism of CASC15. Results LncRNA CASC15 is closely related to tumor development, and has been s...
3 CitationsSource