Emma Patel
Northwood University
Quality assuranceInterquartile rangeInternal medicineRadiologyRandomized controlled trialMedical physicsClinical endpointMultidisciplinary approachCystectomyCommon Terminology Criteria for Adverse EventsQuality (business)Bladder cancerProtocol (science)CredentialingHypofractionated Radiation TherapyBladder DisorderAdaptive radiotherapyComputer scienceConfidence intervalAccrualRadiation therapyClinical trialPlan (drawing)MedicineCohortSelection (genetic algorithm)Image-guided radiation therapy
Publications 5
#1Robert Huddart (ICR: Institute of Cancer Research)H-Index: 83
#2Shaista Hafeez (ICR: Institute of Cancer Research)H-Index: 13
Last. Hybrid InvestigatorsH-Index: 1
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Purpose Hypofractionated radiation therapy can be used to treat patients with muscle-invasive bladder cancer unable to have radical therapy. Toxicity is a key concern, but adaptive plan-of the day (POD) image-guided radiation therapy delivery could improve outcomes by minimizing the volume of normal tissue irradiated. The HYBRID trial assessed the multicenter implementation, safety, and efficacy of this strategy. Methods HYBRID is a Phase II randomized trial that was conducted at 14 UK hospitals...
8 CitationsSource
#1Shaista HafeezH-Index: 13
#2Amanda Webster (Mount Vernon Hospital)H-Index: 2
Last. Robert HuddartH-Index: 83
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Introduction Daily radiotherapy delivered with radiosensitisation offers patients with muscle invasive bladder cancer (MIBC) comparable outcomes to cystectomy with functional organ preservation. Most recurrences following radiotherapy occur within the bladder. Increasing the delivered radiotherapy dose to the tumour may further improve local control. Developments in image-guided radiotherapy have allowed bladder tumour-focused ‘plan of the day’ radiotherapy delivery. We aim to test within a rand...
6 CitationsSource
#1Shaista Hafeez (ICR: Institute of Cancer Research)H-Index: 13
#2Emma Patel (Mount Vernon Hospital)H-Index: 5
Last. Robert Huddart (ICR: Institute of Cancer Research)H-Index: 83
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Introduction Patients with muscle invasive bladder cancer (MIBC) who are unfit and unsuitable for standard radical treatment with cystectomy or daily radiotherapy present a large unmet clinical need. Untreated, they suffer high cancer specific mortality and risk significant disease-related local symptoms. Hypofractionated radiotherapy (delivering higher doses in fewer fractions/visits) is a potential treatment solution but could be compromised by the mobile nature of the bladder, resulting in ta...
14 CitationsSource
#1Emma Patel (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 5
#1Emma Patel (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Robert Huddart (The Royal Marsden NHS Foundation Trust)H-Index: 83
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Abstract Background and Purpose Hypofractionated bladder RT with or without image guided adaptive planning (HYBRID) is a multicentre clinical trial investigating “Plan of the Day” (PoD) adaptive radiotherapy for bladder cancer. To ensure correct PoD selection a pre-accrual guidance and assessment module was developed as part of an image guided radiotherapy quality assurance (IGRT QA) credentialing programme. This study aimed to evaluate its feasibility and effectiveness across multiple recruitin...
9 CitationsSource
#1Y. Tsang (NU: Northwood University)H-Index: 11
#2Angela BakerH-Index: 6
Last. Elizabeth Miles (NU: Northwood University)H-Index: 21
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: •A multi-centre QA programme incorporating adaptive plan selection has been developed.•This novel QA approach has been validated by 71 RTTs from ten UK centres.•A multidisciplinary approach is essential in the development of a credentialing programme.
5 CitationsSource