Yuhua Huang
Soochow University (Suzhou)
CancerSpermatogenesisInternal medicinePhenotypeEndocrinologyWnt signaling pathwaySOX4Blood lipidsSurgeryMagnetic resonance imagingmicroRNALogistic regressionSystems biologyEye movementRetrospective cohort studyRandomized controlled trialRandom forestTest setGene knockdownLigationRegion of interestWilcoxon signed-rank testSleep (system call)Laparoscopic surgeryMechanism of actionProstatePVT1CarcinomaSemen analysisTesticular atrophyVaricoceleLasso (statistics)Semen qualityAldosteroneRadiomicsLuteinizing hormoneRetroperitoneal spaceRapid eye movement sleepInsulinSocial defeatLaparoscopyKidneyProstate cancerBody mass indexBladder cancerGlycemicProstatitisProstaglandinGold standardPathogenesisProstate biopsyEpididymisProstate-specific antigenGonadScrotal PainPositive Surgical MarginTotal adrenalectomyType 2 Diabetes MellitusKidney CarcinomaBacterial prostatitisERECTION PAINSpermatic VeinNuclear medicineSevere painMale circumcisionSleep timeAldosterone producing adenomaLong term resultsHIF1ACalorieAnesthesiaCancer researchEpitheliumTestosteroneTransfectionDiabetes mellitusReceiver operating characteristicCompeting endogenous RNAComputational biologyEffective diffusion coefficientHormoneMedicineTranslational research informaticsBiomarker (medicine)BlotTranscription factorBiology
12Publications
4H-index
38Citations
Publications 15
Newest
#1Jiale Sun (Soochow University (Suzhou))H-Index: 1
#2Wenchang Yue (Soochow University (Suzhou))
Last. Jianquan Hou (Soochow University (Suzhou))H-Index: 14
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Background: Ferroptosis is a newly found nonapoptotic forms of cell death that plays an important role in tumors. However, the prognostic value of ferroptosis-related genes (FRG) in bladder cancer (BLCA) have not been well examined. Methods: FRG data and clinical information were collected from The Cancer Genome Atlas (TCGA). Then, significantly different FRGs were investigated by functional enrichment analyses. The prognostic FRG signature was identified by univariate cox regression and least a...
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#5Jian Zhou (Soochow University (Suzhou))
#6Yuhua Huang (Soochow University (Suzhou))H-Index: 8
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#1Dong He (Soochow University (Suzhou))H-Index: 1
#2Ximing Wang (Soochow University (Suzhou))
Last. Yu-hua Huang (Soochow University (Suzhou))H-Index: 1
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PURPOSE: To investigate the performance of magnetic resonance imaging (MRI)-based radiomics models for benign and malignant prostate lesion discrimination and extracapsular extension (ECE) and positive surgical margins (PSM) prediction. METHODS AND MATERIALS: In total, 459 patients who underwent multiparametric MRI (mpMRI) before prostate biopsy were included. Radiomic features were extracted from both T2-weighted imaging (T2WI) and the apparent diffusion coefficient (ADC). Patients were divided...
1 CitationsSource
#1Xuefu Ji (Changchun University of Science and Technology)H-Index: 1
#2Jiayi Zhang (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Wei Xia (CAS: Chinese Academy of Sciences)H-Index: 11
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The purpose of this study was to develop Bi-parametric Magnetic Resonance Imaging (BP-MRI) based radiomics models for differentiation between benign and malignant prostate lesions, and to cross-vendor validate the generalization ability of the models. The prebiopsy BP-MRI data (T2-Weighted Image [T2WI] and the Apparent Diffusion Coefficient [ADC]) of 459 patients with clinical suspicion of prostate cancer were acquired using two scanners from different vendors. The prostate biopsies are the refe...
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#1Mingwei Chen (Soochow University (Suzhou))H-Index: 1
#2Xuedong Wei (Soochow University (Suzhou))H-Index: 10
Last. Jianquan Hou (Soochow University (Suzhou))H-Index: 14
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Objective: Several reports have proposed that lncRNAs, as potential biomarkers, participate in the progression and growth ofmalignant tumors. HIF1A-AS2 is a novel lncRNA and potential biomarker, involved in the genesis and development of carcinomas.However, the molecular mechanism of HIF1A-AS2 in renal carcinoma is unclear. Methods: The relative expression levels of HIF1A-AS2 and miR-30a-5p were detected using RT-qPCR in renal carcinoma tissuesand cell lines. Using loss-of-function and overexpre...
3 CitationsSource
#1Mingwei Chen (Soochow University (Suzhou))H-Index: 1
#2Rongyuan Zhang (Soochow University (Suzhou))H-Index: 3
Last. Jianquan Hou (Soochow University (Suzhou))H-Index: 14
view all 10 authors...
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#1Yuxin LinH-Index: 12
#2Zhijun MiaoH-Index: 2
Last. Bairong ShenH-Index: 31
view all 7 authors...
Background: Prostate cancer (PCa) is occurred with increasing incidence and heterogeneous pathogenesis. Although clinical strategies are accumulated for PCa prevention, there is still a lack of sensitive biomarkers for the holistic management in PCa occurrence and progression. Based on systems biology and artificial intelligence, translational informatics provides new perspectives for PCa biomarker prioritization and carcinogenic survey. Methods: In this study, gene expression and miRNA-mRNA ass...
2 CitationsSource
#1Xu Xu (Soochow University (Suzhou))H-Index: 2
#2Yuhua Huang (Soochow University (Suzhou))H-Index: 4
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Background Chronic non-bacterial prostatitis (CNP) is a common disease of the male reproductive system. MiR-181c can be expressed in prostate tissue, but it has not been reported in CNP. This study aims to explore the role of miR-181c in CNP and its mechanism of action on CNP, providing new ideas for the treatment and diagnosis of CNP. Methods Quantitative real-time PCR (qRT-PCR) and western blotting were performed to determine the expression of miR-181c in clinical CP patients and LPS-induced h...
2 CitationsSource
#1Mingwei Chen (Soochow University (Suzhou))H-Index: 1
#2Rongyuan Zhang (Soochow University (Suzhou))H-Index: 3
Last. Jianquan Hou (Soochow University (Suzhou))H-Index: 14
view all 10 authors...
Background Numerous studies proved that long non-coding RNA (lncRNA) is involved in the progression of multifarious diseases, especially in some carcinomas. As a potential tumor biomarker, plasmacytoma variant translocation 1 gene (PVT1) is involved in the development and progression of multifarious cancers. Nevertheless, the intrinsic and concrete molecular mechanism of PVT1 in bladder cancer still remained unclear, which is also the dilemma faced in many non-coding RNA studies. Results Our res...
10 CitationsSource
#1Jian Hu Liu (Soochow University (Suzhou))H-Index: 1
#2Xue Dong Wei (Soochow University (Taiwan))H-Index: 1
Last. Yuhua Huang (Soochow University (Taiwan))H-Index: 4
view all 7 authors...
PURPOSE: Laparoscopy surgery is the gold standard for the treatment of aldosterone-producing adenomas (APA). However, the effectiveness between laparoscopic total and partial adrenalectomy is controversial. Therefore, we retrospectively analyzed the postoperative and follow-up outcomes of these two procedures. MATERIALS AND METHODS: A total of 96 APA patients underwent laparoscopic surgery in our hospital between January 2012 and December 2017. A total of 65 patients who underwent laparoscopic p...
3 CitationsSource