R. Ileng Kumaran
Farmingdale State College
PathophysiologyCell cycle checkpointInduced pluripotent stem cellDrug resistanceCancerPhenotypeBone cellSomatic cellStem cell markerWnt signaling pathwayStem cell theory of agingEmbryonic stem cellCell signalingNeuroscienceTelomereCell typeMyocyteNutrient sensingT cellTumor microenvironmentChemotherapyTumour heterogeneitySatellite (biology)Approved drugMelanomaImmunotherapyHeart failureBone healthMetastasisBrain tumorMitophagyStem-cell therapyHoming (hematopoietic)Cellular senescenceALDH1A1Skeletal muscleMedullary thyroid cancerWound healingAngiogenesisOvarian cancerCancer immunotherapyProteostasisStem cellPopulationCell Cycle ProfileStem Cell Self-RenewalCancer metastasisOvarian cancer cellsMitochondrial respirationPreclinical testingCancer biologySignalling pathwaysCisplatin resistantCombination chemotherapyProgrammed cell deathMyogenesisEpigeneticsTissue engineeringCancer researchRadiation therapySenescenceCancer stem cellRadioresistanceCell growthSignal transductionText miningMedicineEpithelial–mesenchymal transitionReprogrammingOncolytic virusPI3K/AKT/mTOR pathwayBiologyActivator (genetics)Immune systemCell biologyCancer cell
12Publications
1H-index
1Citations
Publications 12
Newest
#1Ilangovan Ramachandran (University of Madras)H-Index: 11
#2Sivakumar Ramadoss (UCLA: University of California, Los Angeles)H-Index: 10
Last. Gautam Chaudhuri (UCLA: University of California, Los Angeles)H-Index: 55
view all 6 authors...
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#1Manju Mohan (University of Madras)H-Index: 1
#2Sridhar Muthusami (Karpagam University)H-Index: 1
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
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Abstract Cellular senescence is a hallmark of aging that is characterized by irreversible cell cycle arrest in response to various stress stimuli. It is a normal physiological event, which plays essential role in development, prevention of cancer, wound healing process, etc. Nevertheless, accumulation of senescent cells is the trigger and forms the basis of aging of a tissue/organ and, thus, the organismal aging. During aging, cells display a senescence-associated secretory phenotype (SASP) that...
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#1Selvaraj Jayaraman (Saveetha University)H-Index: 3
#2Ponnulakshmi Rajagopal (Meenakshi Academy of Higher Education and Research)H-Index: 1
Last. Yuvaraj Sambandam (NU: Northwestern University)H-Index: 1
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Abstract In the developmental stages of the embryo, the heart is the primary organ that becomes functional. Diseases of the heart are critical and may lead to sudden demise. Basic and clinical studies have been conducted to find a suitable cure for killer diseases such as myocardial infarction (MI), stroke, and heart failure. One such probable solution to repair and replace the impaired cells noninvasively is the use of stem cell therapy, especially embryonic stem cells (ESCs) and induced plurip...
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#1Ezhilarasan Devaraj (Saveetha University)H-Index: 5
#2Muralidharan Anbalagan (Tulane University)H-Index: 11
Last. Natarajan Bhaskaran (SRU: Sri Ramachandra University)
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Abstract Aging is the age-dependent biochemical change in tissues and the deterioration in the performance of various biological functions, including a significant decline in immune function, that leads to an increased susceptibility to diseases and mortality. A decreased number of stem cells and a reduction in their regenerative capability are linked with the process of aging. The age-associated accumulation of cell-intrinsic factors such as DNA damage response, enhanced reactive oxygen species...
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#1Sivanandane Sittadjody (Wake Forest Institute for Regenerative Medicine)H-Index: 14
#2Aamina Ali (Wake Forest Institute for Regenerative Medicine)
Last. Emmanuel C. Opara (Wake Forest Institute for Regenerative Medicine)H-Index: 34
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Abstract Stem cell therapy plays a central role in regenerative medicine approach to treat certain diseases, and its success lies in the quantity of stem cells and existing niche in the recipient. Similar to somatic cells, stem cells do age driven by various intrinsic and extrinsic factors. The hallmarks of stem cell aging include oxidative stress, telomere attrition, epigenetic modifications, altered microRNAs, defective RNA splicing, loss of proteostasis, change in cell polarity, mitochondrial...
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#1Shabana Thabassum Mohammed Rafi (University of Madras)
#2Yuvaraj Sambandam (NU: Northwestern University)H-Index: 1
Last. R. Ileng Kumaran (Farmingdale State College)H-Index: 1
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Abstract Skeletal muscle tissue-resident muscle stem cells, also called satellite cells, can undergo self-renewal and differentiation via adult myogenesis to generate muscle lineage through adult life. Satellite cells remain dormant in the quiescent state until the muscle suffers an injury. Upon damage to the muscle, the dormant satellite cells are activated, resulting in myogenesis mediated by its microenvironment. There is a progressive decline in the regenerative capacity of the muscles due t...
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#2Sivakumar RamadossH-Index: 10
Last. Gautam ChaudhuriH-Index: 55
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Introduction: Ovarian cancer is one of the most common malignancies among women that causes severe mortality in USA and globally. Despite advances in cancer treatments in the last few decades, there is no substantial improvement in the survival rates of patients with advanced ovarian cancers. This is mainly attributed to drug resistance and tumor recurrence. Most patients develop resistance to platinum compounds, which are often used as the first-line therapy. Several studies have shown that ald...
1 CitationsSource
#1Ilangovan Ramachandran (University of Madras)H-Index: 11
#2Sivakumar Ramadoss (UCLA: University of California, Los Angeles)H-Index: 10
Last. Gautam Chaudhuri (UCLA: University of California, Los Angeles)H-Index: 55
view all 5 authors...
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Last. R. Ileng KumaranH-Index: 1
view all 7 authors...
1 CitationsSource
#1Gautham Chengizkhan (University of Madras)
#2Natarajan Bhaskaran (Case Western Reserve University)H-Index: 16
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
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Tumours are groups of cells, consisting of heterogeneous types of cells that exhibit abnormal cellular characteristics and behaviours. The molecular characteristics of tumour cells can be used to classify the tumour types. In a tumour, the complexity of the population of cell types involved and their diverse gene expression patterns, contribute significantly to tumour heterogeneity, growth, metastasis and aggressiveness. Cancer stem cells (CSCs) are a small population of cells in a tumour that a...
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