Luigi Aloj
University of Cambridge
EpidemiologyGermlineMutation (genetic algorithm)Interquartile rangeDetection limitCancerInternal medicinePET-CTBiomedical engineeringMolecular imagingPathologyMagnetic resonance imagingOncologyCellSomatostatin receptor 2Cytotoxic T cellCD8Randomized controlled trialNeuroscienceAdipose tissueJurkat cellsMaterials scienceCell surface receptorPredictive value of testsIn vitroClinical endpointIn vivoHazard ratioPositron emission tomographyPositron emission tomography–magnetic resonance imagingGiSTGamma counterVasculitisT cellTumor microenvironmentCardiac imagingParagangliomaPatient choiceMelanomaImmunotherapyBevacizumabCarotid bodyGliomaChemotherapy regimenBurkitt's lymphomaBrain tumorRaltitrexedScannerFolinic acidResponse Evaluation Criteria in Solid TumorsProstate cancerRadium-223SDHBImmune checkpointOxaliplatinRegimenIntravital microscopyCastrate-resistant prostate cancerMediastinal ParagangliomaTumor Regression GradeHuman anatomyPatient managementNuclear medicineRadionuclide therapyPet imagingIn patientCell specificMolecular targetingTakayasu arteritisMolecular biomarkersSingle useRare casePet scannerDisease activitySurvival benefitRoutine clinical practicePhases of clinical researchPDGFRACancer researchRadiation therapyPlasma protein binding3D printingClinical trialBioinformaticsMedicineSomatostatin receptorBiologyCell biology
10Publications
2H-index
7Citations
Publications 12
Newest
#1Christopher Wall (University of Cambridge)H-Index: 2
#2Yuan Huang (University of Cambridge)H-Index: 14
Last. Luigi Aloj (University of Cambridge)H-Index: 2
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#1Fulvio Zaccagna (U of T: University of Toronto)H-Index: 17
#2James T. Grist (University of Birmingham)H-Index: 10
Last. Tarik F. Massoud (Stanford University)H-Index: 40
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Molecular imaging techniques have rapidly progressed over recent decades providing unprecedented in vivo characterization of metabolic pathways and molecular biomarkers. Many of these new techniques have been successfully applied in the field of neuro-oncological imaging to probe tumor biology. Targeting specific signaling or metabolic pathways could help to address several unmet clinical needs that hamper the management of patients with brain tumors. This review aims to provide an overview of t...
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#1Antonio AvalloneH-Index: 3
Last. Antonino CassataH-Index: 3
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Importance null Although bevacizumab is a standard of care in combination treatments for metastatic colorectal cancer (mCRC), its clinical benefit has been limited. null Objective null To determine whether sequential scheduling of bevacizumab administration in combination with chemotherapy improves treatment efficacy in patients with mCRC, in keeping with the tumor vascular normalization hypothesis. null Design, Setting, and Participants null This open-label, randomized clinical phase 3 trial wa...
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#1Daniel Gillett (University of Cambridge)H-Index: 7
#2Daniel Marsden (Cambridge University Hospitals NHS Foundation Trust)
Last. Luigi Aloj (University of Cambridge)H-Index: 2
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Purpose Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by creating phantoms which replicate human anatomy which can be filled with radioactive material. The problem with these is that small objects suffer to a greater extent than larger objects from the effects of inactive walls, and therefore, phantoms without these are desirable. The purpose...
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#1John R. BuscombeH-Index: 30
#2Daniel GillettH-Index: 7
Last. Luigi AlojH-Index: 2
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A retrospective analysis was performed of epidemiological data assessing the survival of patients who had received radium-223 for castrate-resistant metastatic prostate cancer treated at a regional tertiary referral center over a 5-year period. The patients' age, date of first treatment, and the number of cycles of radium-223 given were obtained from the patients' electronic patient record (EPR). Data on the date of death were provided by national death registrations which update the EPR via a u...
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#1Luigi Aloj (University of Cambridge)H-Index: 2
#2Olivier Giger (University of Cambridge)H-Index: 5
Last. Ruth T Casey (University of Cambridge)H-Index: 11
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BACKGROUND [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor radionuclide therapy with [177Lu]Lu-DOTATATE. However, somatostatin receptor (SSTR) expression is not unique to NET, and therefore, [68 Ga]Ga-DOTATATE PET/CT may have oncological application in other tumours. Molecular profiling of gastrointestinal stromal tumours that lack act...
1 CitationsSource
#1Luigi Aloj (University of Cambridge)H-Index: 2
#2Bala Attili (University of Cambridge)H-Index: 4
Last. Ferdia A. Gallagher (University of Cambridge)H-Index: 34
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Abstract Targeting specific cell membrane markers for both diagnostic imaging and radionuclide therapy is a rapidly evolving field in cancer research. Some of these applications have now found a role in routine clinical practice and have been shown to have a significant impact on patient management. Several molecular targets are being investigated in ongoing clinical trials and show promise for future implementation. Advancements in molecular biology have facilitated the identification of new ca...
1 CitationsSource
#1Doreen Lau (University of Cambridge)H-Index: 6
#2Fabien GarçonH-Index: 11
Last. Ferdia A. Gallagher (University of Cambridge)H-Index: 34
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This project was supported by the CRUK Cambridge Centre (C9685/A25177) and Cambridge Commonwealth, European and International Trust PhD Scholarship, Cancer Research UK (CRUK; C19212/A16628, C19212/A911376), the CRUK & Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre in Cambridge and Manchester (C197/A16465) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre.
6 CitationsSource
#1Laura M. Lechermann (University of Cambridge)H-Index: 2
#2Roido Manavaki (University of Cambridge)H-Index: 9
Last. Ferdia A. Gallagher (University of Cambridge)H-Index: 34
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PURPOSE Tracking cells in vivo using imaging can provide non-invasive information to understand the pharmacology, efficacy, and safety of novel cell therapies. Zirconium-89 (t1/2 = 78.4 h) has recently been used to synthesize [89Zr]Zr(oxinate)4 for cell tracking using positron emission tomography (PET). This work presents an in vitro approach to estimate the detection limit for in vivo PET imaging of Jurkat T cells directly labeled with [89Zr]Zr(oxinate)4 utilizing clinical PET/CT and PET/MRI. M...
2 CitationsSource
#1Jason M. Tarkin (University of Cambridge)H-Index: 15
#2Christopher Wall (University of Cambridge)H-Index: 2
Last. Justin C. Mason (NIH: National Institutes of Health)H-Index: 62
view all 11 authors...
6 CitationsSource