Chen Yang
Shenzhen University
BiophysicsCatalysisChemistryMaterials scienceIn vitroIn vivoSuperoxide dismutaseGlucose oxidaseAntioxidantCatalaseAcute kidney injuryBone regenerationReactive oxygen speciesTissue engineeringCancer researchHydrogen peroxideBiochemistryNanodotScaffoldPharmacology
13Publications
4H-index
54Citations
Publications 12
Newest
#1Dong-Yang ZhangH-Index: 2
#2Hengke LiuH-Index: 3
Last. Peng HuangH-Index: 103
view all 8 authors...
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#1Dong-Yang ZhangH-Index: 2
#2Hengke LiuH-Index: 3
Last. Peng HuangH-Index: 103
view all 8 authors...
Abstract Acute kidney injury (AKI) is a common kidney disease with high mortality rate, while surprisingly, the supportive treatment and renal replacement are the only available clinical treatment options to date. The onset of AKI is often triggered by excessive toxic reactive oxygen/nitrogen species (RONS), and hence, the development of antioxidants with high renal accumulation and effective renal clearance is highly demanded to consume RONS in the kidneys. In this study, we developed ultrasmal...
2 CitationsSource
#1Chen Yang (SZU: Shenzhen University)H-Index: 4
#2Rui Zheng (First Affiliated Hospital of Wenzhou Medical University)
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 9 authors...
Abstract Near-infrared (NIR) light-responsive shape-memory composites have shown great potential in various biomedical applications due to their amazing remote actuation property. However, most of them are bioinert and restricted in NIR-I biological window. Here, we developed a new biodegradable NIR-II-responsive shape memory composite by the incorporation of CaSiCu4O10 nanosheets (CUP NSs) into shape memory polymer of poly (D, L-lactide-co-trimethylene carbonate) (PDLLA-co-TMC, denoted as PT). ...
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#1Chen YangH-Index: 4
#2Xiaoting GaoH-Index: 3
Last. Jing Lin (SZU: Shenzhen University)H-Index: 64
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Abstract Although numerous biomaterials are fabricated as scaffolds for the application of tissue engineering, real-time non-invasive monitoring of in vivo bone regeneration is still a big challenge. Especially during early osteogenesis, which is difficult to detect using conventional imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) due to the limited amount of neo-bone tissue. Herein we report on alkaline phosphatase (ALP)-responsive scaffolds, whi...
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#1Chen Yang (SZU: Shenzhen University)H-Index: 4
#2Zhiwei Zheng (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 12 authors...
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#1Dong-Yang Zhang (SZU: Shenzhen University)H-Index: 2
#2Hengke Liu (SZU: Shenzhen University)H-Index: 3
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 10 authors...
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#1Dong-Yang Zhang (SZU: Shenzhen University)H-Index: 2
#2Hengke Liu (SZU: Shenzhen University)H-Index: 3
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 10 authors...
Acute kidney injury (AKI) is frequently triggered by abundant reactive oxygen/nitrogen species (RONS) and leads to high morbidity and mortality in clinic. Unfortunately, the current clinical treatment options are only limited to supportive care, and hence, the development of nano-antioxidants with high kidney enrichment is an attractive novel strategy for AKI management. Herein, self-assembled ultrasmall nanodots are reported that consist of iron ion, gallic acid, and polyvinylpyrrolidone (denot...
1 CitationsSource
#1Lian-Hua Fu (SZU: Shenzhen University)H-Index: 17
#1Lian-Hua Fu (SZU: Shenzhen University)
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 9 authors...
2 CitationsSource
#1Lian-Hua Fu (SZU: Shenzhen University)
#1Lian-Hua Fu (SZU: Shenzhen University)H-Index: 17
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 9 authors...
Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of the insufficient endogenous H2 O2 and the high concentration of glutathione (GSH) in tumor cells, an intelligent nanocatalytic theranostics (denoted as PGC-DOX) that possesses both H2 O2 self-supply and GSH-elimination properties for efficient cancer therapy is presented. This nan...
5 CitationsSource
#1Dong-Yang Zhang (SZU: Shenzhen University)H-Index: 2
#2Hengke Liu (SZU: Shenzhen University)H-Index: 3
Last. Peng Huang (SZU: Shenzhen University)H-Index: 103
view all 9 authors...
Rhabdomyolysis-induced acute kidney injury (AKI) is closely related to abundant reactive oxygen species (ROS). Owing to the multi-enzymatic activity and broad-spectrum ROS scavenging capacity of ceria nanoparticles (ceria NPs), herein, we report ultrasmall citric acid modified ceria nanozymes (3-4 nm) as antioxidants to alleviate rhabdomyolysis-induced AKI through removing excessive ROS. The as-prepared ceria NPs exhibited multi-enzymatic properties such as peroxidase, catalase, and superoxide d...
3 CitationsSource