Soonjae Hwang
Yonsei University
Denaturation (biochemistry)CD90CancerBiophysicsInternal medicineEndocrinologyAntibodyAdipose tissueTumor necrosis factor alphaChemistryParticle sizeApoptosisMesenchymal stem cellIn vitroIn vivoHydrodynamic radiusColitisHydroxideZingiber zerumbetInterferonBALB/cRed blood cellInflammationCell-penetrating peptideHepatocyte growth factorCecumNitric oxide synthaseNF-?BProstaglandin E2MyoDGliomaInflammatory bowel diseaseAzoxymethaneContext (language use)Bacteroides fragilisProstaglandinStem cellPopulationBinding constantSecretionCancer researchNitric oxideBacteriaColorectal cancerTransfectionCancer stem cellCarcinogenesisMetalloproteinaseCell growthMedicineInterleukinParacrine signallingZeta potentialBiologyMicrobiologyCell biologyCancer cellPharmacology
9Publications
2H-index
23Citations
Publications 10
Newest
#1Seongyup Kim (Yonsei University)H-Index: 5
#2Pil Young Jung (Yonsei University)H-Index: 4
Last. Young Woo Eom (Yonsei University)H-Index: 17
view all 8 authors...
Skeletal muscle satellite cells (SkMSCs) play crucial roles in muscle fiber maintenance, repair, and remodeling; however, it remains unknown if these properties are preserved in cultured SkMSCs. In this study, we investigated the characteristics of cultured SkMSCs and their ability to regulate the activity of M1 macrophages. SkMSCs grew well with an average population doubling time of 26.26 ± 6.85 h during 10 passages (P). At P5, Pax7, MyoD, cluster of differentiation (CD)34, and CD56 were not e...
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#1Young Un Choi (Yonsei University)H-Index: 4
#2Yongdae Yoon (Yonsei University)
Last. Young Woo Eom (Yonsei University)H-Index: 17
view all 10 authors...
Background/aim null Mesenchymal stem cell-based tumor therapy is still limited due to the insufficient secretion of effectors and discrepancies between their in vitro and in vivo efficacy. We investigated whether genetically engineered adipose tissue-derived mesenchymal stem cells (ASCs) overexpressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) had inhibitory effects on H460 tumor growth both in vitro and in an H460 xenograft model. null Materials and methods null Geneticall...
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#1Jaesik Shin (Yonsei University)
#2Soon Koo Baik (Yonsei University)H-Index: 42
Last. Young Woo Eom (Yonsei University)H-Index: 17
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BACKGROUND/AIM Genetic manipulation of stem cells using non-viral vectors is still limited due to low transfection efficiency. We investigated whether the DNA-binding cell-permeation peptides (CPP) can enhance the transfection efficiency of non-viral vectors in adipose tissue-derived mesenchymal stem cells (ASCs) and whether ASCs over-expressing TRAIL through CPP can inhibit the growth of glioma U251MG cells in vitro and in vivo. MATERIALS AND METHODS ASCs were genetically engineered to over-exp...
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#1Sang-Yong Jung (Dongguk University)H-Index: 1
#1Sang-Yong JungH-Index: 1
Last. Jae-Min OhH-Index: 20
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A layered double hydroxide (LDH)-based anticancer delivery system was investigated in terms of crystalline phase, particle size, hydrodynamic radius, zeta potential, etc. through in vitro and in vivo study. Size controlled LDH with anticancer drug methotrexate (MTX) incorporation was successfully prepared through step-by-step hydrothermal reaction and ion-exchange reaction. The MTX-LDH was determined to have a neutral surface charge and strong agglomeration in the neutral aqueous condition due t...
1 CitationsSource
#1Soonjae Hwang (KIST: Korea Institute of Science and Technology)H-Index: 2
#1Soonjae Hwang (KIST: Korea Institute of Science and Technology)
Last. Ki Jong Rhee (College of Health Sciences, Bahrain)H-Index: 19
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Consumption of a Western-type diet has been linked to gut-microbiota-mediated colon inflammation that constitutes a risk factor for colorectal cancer. A high salt diet (HSD) exacerbates IL-17A-induced inflammation in inflammatory bowel disease and other autoimmune diseases. Enterotoxigenic Bacteroides fragilis (ETBF) is a gut commensal bacterium and reported to be a potent initiator of colitis via secretion of the Bacteroides fragilis toxin (BFT). BFT induces ectodomain cleavage of E-cadherin in...
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#1Young Woo Eom (Yonsei University)H-Index: 17
#2Rokeya Akter (Yonsei University)H-Index: 1
Last. Mee Yon Cho (Yonsei University)H-Index: 20
view all 7 authors...
We have previously reported that adipose tissue-derived stem cells (ASCs) cultured at high cell density can induce cancer cell death through the expression of type I interferons and tumor necrosis factor (TNF)-related apoptosis-inducing ligands (TRAIL). Here, we investigated whether TRAIL-expressing ASCs induced by M1 macrophages can alleviate colitis-associated cancer in an azoxymethane (AOM)/dextran sodium sulfate (DSS) animal model. M1 macrophages significantly increased the TRAIL expression ...
1 CitationsSource
#1Chun Sung Byun (Yonsei University)H-Index: 8
#2Soonjae Hwang (Yonsei University)H-Index: 2
Last. Young Woo Eom (Yonsei University)H-Index: 17
view all 11 authors...
: Interferon (IFN)-β and/or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) secreted by adipose tissue-derived mesenchymal stem cells (ASCs) have been proposed as key mechanistic factors in anti-cancer efficacy in lung cancer and breast cancer cells, where they act through paracrine signaling. We hypothesized that IFN-β and TRAIL produced by ASCs suppress proliferation of hepatocellular carcinoma cells (HCCs). The present study evaluated the anti-cancer effects of ASCs on HCCs in...
3 CitationsSource
#1Soonjae Hwang (Yonsei University)H-Index: 2
#2Minjeong Jo (College of Health Sciences, Bahrain)H-Index: 4
Last. Ki Jong Rhee (College of Health Sciences, Bahrain)H-Index: 19
view all 6 authors...
Chronic inflammation has been linked to colitis-associated colorectal cancer in humans. The human symbiont enterotoxigenic Bacteroides fragilis (ETBF), a pro-carcinogenic bacterium, has the potential to initiate and/or promote colorectal cancer. Antibiotic treatment of ETBF has shown promise in decreasing colonic polyp formation in murine models of colon cancer. However, there are no reported natural products that have shown efficacy in decreasing polyp burden. In this study, we investigated the...
2 CitationsSource
#1Soonjae Hwang (College of Health Sciences, Bahrain)H-Index: 5
#1Soonjae Hwang (Yonsei University)H-Index: 2
Last. Ki Jong RheeH-Index: 19
view all 11 authors...
The azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model is commonly used to study colitis-associated cancer. The human commensal bacterium, enterotoxigenic Bacteroides fragilis (ETBF) secretes the Bacteroides fragilis toxin (BFT) which is necessary and sufficient to cause colitis. We report that BALB/c mice infected with WT-ETBF and administered three cycles of AOM/DSS developed numerous, large-sized polyps predominantly in the colorectal region. In addition, AOM/DSS-treated BALB/c mice...
9 CitationsSource
#1Soonjae Hwang (Yonsei University)H-Index: 2
#2Minjeong Jo (College of Health Sciences, Bahrain)H-Index: 4
Last. Ki Jong Rhee (College of Health Sciences, Bahrain)H-Index: 19
view all 7 authors...
Enterotoxigenic Bacteroides fragilis (ETBF) is human intestinal commensal bacterium and a potent initiator of colitis through secretion of the metalloprotease Bacteroides fragilis toxin (BFT). BFT induces cleavage of E-cadherin in colon cells, which subsequently leads to NF-κB activation. Zerumbone is a key component of the Zingiber zerumbet (L.) Smith plant and can exhibit anti-bacterial and anti-inflammatory effects. However, whether zerumbone has anti-inflammatory effects in ETBF-induced coli...
9 CitationsSource