Claudia Benedetti
Icahn School of Medicine at Mount Sinai
Internal medicineWnt signaling pathwayVirologyAntibodyCD8Organ transplantationExtracellular matrixAcquired immune systemMesenchymal stem cellImmunologyT cellImmunoglobulin MInflammationHemodialysisBetacoronavirusKidney diseaseDialysisKidneyImmunosuppressionAcute kidney injuryFibrosisImmunoglobulin GPopulationMild proteinuriaTransplantation2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Cancer researchNephrologyMedicineImmune systemPandemicGastroenterologyDiffuse alveolar damage
4Publications
3H-index
37Citations
Publications 4
Newest
#1Susan Hartzell (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
#2Sofia Bin (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
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Whether kidney transplant recipients are capable of mounting an effective anti-SARS-CoV-2 adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18 kidney transplant recipients with active COVID-19 infection and 36 matched, transplanted controls without COVID-19. We observed significantly fewer t...
11 CitationsSource
#1Gianluigi ZazaH-Index: 30
#2Claudia BenedettiH-Index: 3
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
view all 7 authors...
After the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Wuhan, China, in December 2019, the contagion has spread rapidly and has become a global pandemic.(1) There are as of yet no published studies beyond the case series describing the incidence and clinical course of COVID-19 in transplant recipients, a population potentially at high risk due to the ongoing immunosuppression and higher risk of comorbidities.(2) This pandemic has had a major im...
2 CitationsSource
#1Claudia Benedetti (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#2Meryl Waldman (NIH: National Institutes of Health)H-Index: 16
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
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Novel coronavirus disease 2019 (COVID-19) has become a worldwide emergency health problem. The disease occurs mostly in individuals between 30-79 years of age and 81% of cases are mild. However, it may result in progressive respiratory failure owing to alveolar damage and can be fatal in 3.6% of the cases. Direct viral injury, uncontrolled inflammation, and activation of coagulation and complement cascades are thought to participate in disease pathogenesis. Patients with COVID-19 often display k...
17 CitationsSource
#1Simona GranataH-Index: 17
#2Claudia BenedettiH-Index: 3
Last. Gianluigi ZazaH-Index: 30
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To add new molecular and pathogenetic insights into the biological machinery associated to kidney allograft fibrosis is a major research target in nephrology and organ transplant translational medicine. Interstitial fibrosis associated to tubular atrophy (IF/TA) is, in fact, an inevitable and progressive process that occurs in almost every type of chronic allograft injury (particularly in grafts from expanded criteria donors) characterized by profound remodeling and excessive production/depositi...
1 CitationsSource