Haonan Zong
Boston University
Chemical specificityOpticsImage formationFar-infrared laserOrders of magnitude (temperature)MicroscopyInfraredHyperspectral imagingInterferometryPhotothermal therapyScatteringMaterials scienceImage resolutionPhotothermal effectCharacterization (materials science)Chemical fingerprintingPhotobleachingOptoelectronicsLaserAbsorption (electromagnetic radiation)Chemical imagingMicroscopeResolution (electron density)
15Publications
2H-index
27Citations
Publications 5
Newest
#2Haonan ZongH-Index: 2
Last. M. Selim ÜnlüH-Index: 3
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Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal the specimen's size and shape information, the chemical composition is inaccessible in interferometric measurements. Infrared spectroscopic imaging provides chemical specificity based on inherent chemical bond vibrations of specimens but lacks the ability to i...
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#1Yi Zhang (BU: Boston University)H-Index: 4
#2Haonan Zong (BU: Boston University)H-Index: 2
Last. Ji-Xin ChengH-Index: 83
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Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at submicrometer spatial resolution and enables infrared spectroscopy and imaging of living cells and organisms. Yet, current mid-infrared photothermal imaging sensitivity suffers from a weak dependence of scattering on the temperature, and the image quality is vulnerable to...
1 CitationsSource
#1Haonan ZongH-Index: 2
Last. Ji-Xin ChengH-Index: 83
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Mid-infrared photothermal (MIP) microscopy has been a promising label-free chemical imaging technique for functional characterization of specimens owing to its enhanced spatial resolution and high specificity. Recently developed wide-field MIP imaging modalities have drastically improved speed and enabled high-throughput imaging of micron-scale subjects. However, the weakly scattered signal from sub-wavelength particles becomes indistinguishable from the shot-noise as a consequence of the strong...
2 Citations
#1Haonan Zong (BU: Boston University)H-Index: 2
#2Celalettin Yurdakul (BU: Boston University)H-Index: 7
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
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Mid-infrared photothermal microscopy (MIP) has been a promising chemical imaging technique for functionality characterization of biological and pharmaceutical specimens owing to its enhanced resolution and high-specificity. Recently developed wide-field MIP modalities drastically improved the imaging speed and thus enabled high-throughput imaging. However, the sensitivity of the wide-field MIP technique has been limited by shot-noise of background photons. Here, we demonstrate a dark-field MIP m...
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#1Yi Zhang (BU: Boston University)H-Index: 4
#2Zong Cheng (BU: Boston University)
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 5 authors...
Mid-infrared photothermal (MIP) imaging is an emerging technique where a visible beam is deployed to sense the photothermal lensing effect induced by infrared absorption of molecules. This technology provides sub-micron spatial resolution defined by the visible probe beam. Yet, the photothermal lensing effect is a weak effect for most materials. For instance, the diffraction coefficient of poly (methyl methacrylate) changes around 0.1% per Kelvin. Thus, highly sensitive probes are desired to imp...
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