Yudan Wang
Nanchang University
ChemokineKEGGReceptorTight junctionTumor necrosis factor alphaBiochemical engineeringChemistryApoptosisCaco-2AutophagyStimulationCytokine receptorColitisCytokineUlcerative colitisFlexibility (engineering)ATG5Intestinal epitheliumIntestinal cellIntestinal MetabolismIntestinal absorptionIntestinal immunityFuture studyIntestinal transportComputer scienceMAPK/ERK pathwaySignal transductionProtein kinase BPI3K/AKT/mTOR pathwayImmune systemCell biology
4Publications
2H-index
6Citations
Publications 4
Newest
#1Yudan Wang (NCU: Nanchang University)H-Index: 2
#2Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
Last. Qiang Yu (NCU: Nanchang University)H-Index: 21
view all 9 authors...
Abstract The previous research has indicated that Ganoderma atrum polysaccharide (PSG-1) indirectly affects the immune function of dendritic cells (DCs) in intestinal-like Caco-2/DCs co-culture model, in which NF-κB and MAPK pathway play an essential role. To explore the interaction of Caco-2 in the interaction between the intestinal epithelium and its internal immune cells, the intestinal-like Caco-2/DCs co-culture model was developed. All transcripts of Caco-2 treated with or without PSG-1 wer...
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#1Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
#2Xiaoyi Hu (NCU: Nanchang University)H-Index: 3
Last. Qiang Yu (NCU: Nanchang University)H-Index: 21
view all 7 authors...
Abstract Background Food-intestine interaction study has always been a hot topic in food science and nutrition due to diverse physiological functions of intestine. Compared to expensive animal models with limited screening capabilities, the simple, reliable and highly reproducible intestinal cell models are widely used in food-intestine interaction study. There are many functional cell models used to simulate the intestine in vitro, among which the Caco-2 cell model is one of the most widely use...
2 CitationsSource
#1Bing ZhengH-Index: 3
#2Mengxi YingH-Index: 3
Last. Qiang YuH-Index: 21
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Polysaccharides are one of the main active substances in Ganoderma atrum (G. atrum). The purpose of this study was to explore the protective effect of a G. atrum polysaccharide (PSG-1) on DSS-induced colitis and the underlying mechanism. The results showed that PSG-1 could maintain the integrity of the intestinal structure by promoting the expression of goblet cells and levels of tight junction proteins in the colon of DSS-induced colitis mice. Furthermore, PSG-1 relieved the inhibition of Bcl-2...
1 CitationsSource
#1Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
#2Qiang Yu (NCU: Nanchang University)H-Index: 21
Last. Mingyong Xie (Jiangxi Normal University)H-Index: 71
view all 9 authors...
Abstract Our previous study has demonstrated that Ganoderma atrum polysaccharide (PSG-1) activated the immune response of dendritic cells (DCs) by direct contacting with surface receptors. However, as a kind of macromolecule compound, PSG-1 cannot directly stimulate DCs via passing through the intestine epithelial cells. To investigate the role of PSG-1 in the interaction between the intestinal epithelium and its internal immune cells, the intestinal-like Caco-2/DCs co-culture model was establis...
3 CitationsSource