Changyin Yu
Zunyi Medical College
Caspase 3Hippocampal formationChemistryApoptosisMesenchymal stem cellAdult stem cellNeuroprotectionMitochondrial ROSNeurotoxicityHoming (hematopoietic)AxonHippocampusStem cellTransplantationProgrammed cell deathMorris water navigation taskp38 mitogen-activated protein kinasesMedicineCell biologyCaspase
4Publications
3H-index
17Citations
Publications 5
Newest
#1Kuang Wei (Zunyi Medical College)H-Index: 1
#2Tao Liu (Zunyi Medical College)H-Index: 2
Last. Changyin Yu (Zunyi Medical College)H-Index: 3
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#1Kuang Wei (Zunyi Medical College)H-Index: 1
#2Tao Liu (Zunyi Medical College)H-Index: 2
Last. Changyin Yu (Zunyi Medical College)H-Index: 3
view all 6 authors...
The purpose of this study is to observe the effect of icariside II (ICS II) on the differentiation of human amniotic mesenchymal stem cells (hAMSCs) into dopaminergic neuron-like cells, the involvement of PI3K signaling pathway inhibitors. After identifying hAMSCs by flow cytometry, hAMSCs were induced and treated with ICS II at 10 μmol/L, 3 μmol/L, 1 μmol/L, and 0 μmol/L. hAMSCs in the LY294002+3μM ICS II group were pretreated with 20 μmol/L LY294002, a PI3K-specific inhibitor, for 1 h, and the...
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#1Nana ChenH-Index: 2
#2Jiao WangH-Index: 1
Last. Jianmei GaoH-Index: 9
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Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer's disease (AD) pathogenesis. Thus inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The development of agent candidates by cultured neurons against Aβ-induced cytotoxicity is widely accepted to be an efficient strategy to explore the drug for AD patients. Previously, we have revealed that trilobatin (TLB), a small molecule monomer, ...
4 CitationsSource
#1Fang HeH-Index: 2
#2Changyin YuH-Index: 3
Last. Huilin JiaH-Index: 1
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Recently, breakthroughs have been made in the use of mesenchymal stem cells (MSCs) to treat various diseases. Several stem cell types have been authorized as drugs by the European Medicines Agency and the U.S. Food and Drug Administration. The Chinese official document “Notification of the management of stem cell clinical research (trial)” was also published in August 2015. Currently, China has approved 106 official stem cell clinical research filing agencies and 62 clinical research projects, w...
10 CitationsSource
#1Tao Liu (Zunyi Medical College)H-Index: 2
#2Fang He (Zunyi Medical College)H-Index: 2
Last. Changyin Yu (Zunyi Medical College)H-Index: 3
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Chronic cerebral hypoperfusion (CCH) is a basic pathological process that is comorbid with brain diseases, such as vascular Parkinsonism and Alzheimer’s disease. Icariside II (ICS II), which is one of the main metabolites of icariin, has anti-inflammatory and antioxidant effects and protects against ischemic brain injury. This study aims to investigate the neuroprotective effects of ICS II on neuronal axon regeneration-related factors in a CCH rat model. Sprague-Dawley (SD) rats were divided int...
5 Citations