Lin Sun
Shenyang Pharmaceutical University
Therapeutic effectNephrotoxicityIonChemical compositionMass spectrometryFourier transform ion cyclotron resonanceHigh-performance liquid chromatographyChemistryDecoctionMetabolic pathwayRadixMetabolomicsMechanism of actionRheum palmatumLiver injuryFormic acidAcetonitrilePhenolsUrineTriterpeneBiomarker (cell)AnthraquinonesPhenylethanoidAurantii fructus immaturusGlycyrrhizae RadixToxicityChemical constituentsPhenylpropanoid glycosidesKetone bodiesChromatographyLipid metabolismLiquid chromatography–mass spectrometryPharmacology
5Publications
1H-index
1Citations
Publications 5
Newest
#1Xu Yan (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
Knoxiae Radix (HDJ, usually used after being processed into CHDJ) is a traditional Chinese herbal medicine that has been recorded in the Chinese Pharmacopoeia for years. It is said that Glycyrrhizae Radix et Rhizoma (GC) is incompatible with HDJ, but few studies can prove this. In this work, non-targeted metabolomics experiments were performed on rats to evaluate the effect of the combination of the two herbals. For this, we conducted a 28-day administration in rats. The plasma, urine and kidney...
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#1Jingwei Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
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Duzhong Jiangya Tablet is a hypotensive drug. In this study, High-performance liquid chromatography-fourier transform-ion cyclotron resonance-mass spectrometry technology was used to quickly identify its chemical composition. SinoChrom ODS-BP column (250mm×4.6mm, 5μm) was used. The mobile phase was acetonitrile(A)-0.1% formic acid solution(B). The flow rate was 1 mL·min-1 . Extracted ion chromatogram was used to analyze the samples in positive and negative ion modes. Based on the obtained accura...
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#1Lin Sun (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
Shaoyao Gancao decoction (SGD), a well-known Chinese herbal formula, has been used to treat liver injury for a long time. In this study, chemical profiles of SGD were identified using ultra high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS/MS). Liquid chromatography was performed on a C18 column (150 mm × 2.1 mm, 1.8 μm); the mobile phase comprised 0.1% formic acid (A) and acetonitrile (B). We then characterized 73 c...
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#1Yanhui Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Sanhua decoction, a famous Chinese herbal formula has been widely used for the treatment of stroke. In our study, a rapid, swift and straightforward analytical method with the help of UHPLC-FT-ICR-MS/MS was successfully developed for the first time to separate and identify the chemical constituents of Sanhua decoction. Chromatography was performed on a Universal XB C18 column (150 mm × 2.1 mm, 1.8 μm) using a mobile phase containing 0.1% formic acid–water (A) and acetonitrile (B). A total of 137...
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#1Lin Sun (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Shaoyao Gancao decoction (SGD) is a famous Chinese traditional prescription for treating liver injury. In this research, we investigated the liver protective effects of SGD and its metabolic mechanisms by 1 H-NMR and UPLC-MS. Serum biochemical indicators and histopathological methods werae used to identify the status of SGD in treating liver injury. An OPLS-DA method was used to screen potential differential metabolic markers, and the MetaboAnalyst and KEGG PATHWAY databases were used to find re...
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