Kiavash Hushmandi
University of Tehran
Cell cycle checkpointCancerWnt signaling pathwaymicroRNAChemistryApoptosisSmall interfering RNAPTENCurcuminMetastasisOncogeneDoxorubicinCancer researchRadiation therapySignal transductionMedicineProtein kinase BTranscription factorPI3K/AKT/mTOR pathwayBiologyCancer cell
66Publications
10H-index
260Citations
Publications 72
Newest
#1Kothanahally S. Sharath Kumar (University of Mysore)H-Index: 12
Last. Firoz Babu Kadumudi (DTU: Technical University of Denmark)H-Index: 7
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Abstract null null The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylet...
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#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
#2Mohammad Hossein Gholami (IAU: Islamic Azad University)H-Index: 3
Last. Gorka Orive (UPV/EHU: University of the Basque Country)H-Index: 68
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P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, to reveal their participation in DOX resistance. These antitumor compounds and genetic tools synergistically reduce P-gp expression. Furthermore, ATP depletion impairs P-gp activity to enhance the antitumor activity of DOX. Nanoarchitectures, including liposomes, micelles, pol...
1 CitationsSource
#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
Last. Amir R. Aref (Harvard University)H-Index: 26
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The proliferation, metastasis and therapy response of tumour cells are tightly regulated by interaction among various signalling networks. The microRNAs (miRNAs) can bind to 3'-UTR of mRNA and down-regulate expression of target gene. The miRNAs target various molecular pathways in regulating biological events such as apoptosis, differentiation, angiogenesis and migration. The aberrant expression of miRNAs occurs in cancers and they have both tumour-suppressor and tumour-promoting functions. On t...
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#1Anuradha Kirtonia (Amity University)H-Index: 6
#2Milad Ashrafizadeh (Sabancı University)H-Index: 9
Last. Vinit Kumar (Amity University)H-Index: 11
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Acute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resulted from blocked myeloid differentiation and an enhanced number of immature myeloid progenitors. During several decades, different factors, including cytogenetic, genetic, and epigenetic have been reported to contribute to the pathogenesis of AML by inhibiting the differentiation and ensuring the proliferation of myeloid blast cells. Recently, long noncoding RNAs (lncRNAs) have been considered as ...
1 CitationsSource
#1Milad Ashrafizadeh (Sabancı University)H-Index: 9
#2Ali Zarrabi (Sabancı University)H-Index: 20
Last. Alan Prem Kumar (NUS: National University of Singapore)H-Index: 68
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Abstract null null Cancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Phytochemicals, in view of their pharmacological activities and capacity to target various molecular pathways, are of great interest in the development of therapeutics against cancer...
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#1Mahshid Deldar Abad Paskeh (IAU: Islamic Azad University)
#2Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
Last. Amir R. Aref (Harvard University)H-Index: 26
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Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to regulation of different cellular events that are necessary for maintaining physiological condition. Dysregulation of miRNAs is correlated with development of various pathological events such as neurological disorders, cardiovascular diseases, and cancer. miRNA-489 is a new emerging miRNA and studies are extensively investigating...
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#1Salman Daneshi (Jiroft University)H-Index: 1
#2Farbod Ebadi Fard Azar (IUMS: Iran University of Medical Sciences)H-Index: 11
Last. esmat Rezabeigi davarani (KMU: Kerman Medical University)H-Index: 1
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Abstract null null Background null Understanding tuberculosis (TB) treatment programs' process and the outcome is one of the critical strategies to prevent the disease's occurrence and accelerate achieving sustainable development goals to reduce TB cases. The present study aimed to evaluate directly observed treatment short-course (DOTs) for tuberculosis. null null null Methods null The present cross-sectional, descriptive-analytical study extracted information from the tuberculosis surveillance...
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#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 5
#2Mahshid Deldar Abad Paskeh (IAU: Islamic Azad University)
Last. Shahin Aghamiri (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
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The clinical management of bladder cancer (BC) has become an increasing challenge due to high incidence rate of BC, malignant behavior of cancer cells and drug resistance. The non-coding RNAs are considered as key factors involved in BC progression. The long non-coding RNAs (lncRNAs) are RNA molecules and do not encode proteins. They have more than 200 nucleotides in length and affect gene expression at epigenetic, transcriptional and post-transcriptional phases. The lncRNAs demonstrate abnormal...
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#1Esmat Rezabeigi-Davarani (KMU: Kerman Medical University)
#2Saied Bokaie (UT: University of Tehran)H-Index: 11
Last. Salman Daneshi (Jiroft University)H-Index: 1
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Background & Objective: The behavior of COVID-19, clinical symptoms, and mortality rate are not the same in different regions Due to lack of knowledge about the cited issues, we aimed to investigate the clinical symptoms, case fatality rate, and some risk factors of COVID-19 Materials & Methods: This longitudinal study was started from the late February 2020 and lasted to the mid-July 2020 in Jiroft, Kerman province, Iran The course of the disease, clinical signs and symptoms, underlying disease...
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#1Sina Heydari (Imam Khomeini Hospital)
#2Najmeh Alizadeh (Imam Khomeini Hospital)
Last. Salman Daneshi (Jiroft University)H-Index: 1
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Background: Distal radius fracture is a common type of bone fracture in patients of all ages. Most of the complications of this type of fracture are related to intra-articular fractures. Aim: This ...
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