Linli Shi
Boston University
NeuriteBiological neural networkTemporal resolutionFibroinBiophysicsBiomedical engineeringNanomaterialsUltrasoundPatch clampNeuromodulation (medicine)Regeneration (biology)ElectrophysiologyChemistryMaterials scienceOptical fiberIn vitroAcoustic waveImage resolutionEnergy conversion efficiencyIn vivoDiffractionStimulationCalcium imagingDorsal root ganglionNeuronCoatingSlice preparationBrain stimulationA fibersNeural stimulationTransient (oscillation)Coupling (electronics)Common emitterOptoelectronicsFiberLaserPhotoacoustic imaging in biomedicineModulationMillisecondDiffusion layerSonoporationPulse (signal processing)ScaffoldSensory system
8Publications
1H-index
5Citations
Publications 8
Newest
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 9 authors...
Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments. Here, we developed a tapered fiber optoacoustic emitter (TFOE) generating an ultrasound field with a high spatial precision of 39.6 µm, enabling optoacoustic activation of single neurons or subcellular structures, such as axons and dendrites. Temporally, a single acoustic pulse of sub-microsecond converted by the TFOE from a s...
Source
#1Nan ZhengH-Index: 1
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 6 authors...
Neural interfaces using biocompatible scaffolds provide crucial properties for the functional repair of nerve injuries and neurodegenerative diseases, including cell adhesion, structural support, and mass transport. Neural stimulation has also been found to be effective in promoting neural regeneration. This work provides a new strategy to integrate photoacoustic (PA) neural stimulation into hydrogel scaffolds using a nanocomposite hydrogel approach. Specifically, polyethylene glycol (PEG)-funct...
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 4 authors...
Towards non-genetic, precise neural stimulation, we develop a photoacoustic neural stimulation technology. It employs a fiber-based optoacoustic process, in which pulsed light is delivered through an optical fiber into an absorbing layer coated at the tip, resulting in transient heating and generating a localized acoustic wave. We report photoacoustic stimulation in vitro and in vivo through a lab-built fiber based optoacoustic emitter (FOE). Single neuron optoacoustic neural modulation is achie...
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#1Ying Jiang (BU: Boston University)H-Index: 4
#2Yimin Huang (BU: Boston University)H-Index: 10
Last. Lu Lan (BU: Boston University)H-Index: 12
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Summary Neuromodulation is an invaluable approach for the study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation in vitro and in vivo. Our PANs strongly absorb the nanosecond pulsed laser in the near-infrared second window (NIR-II) and generate localized acoustic waves. PANs are shown to be surface modified and selectively bind onto neurons. PAN-mediated activ...
1 CitationsSource
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 9 authors...
As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet, the spatial resolution of ultrasound does not allow for high-precision stimulation. Here, we developed a tapered fiber optoacoustic emitter (TFOE) for optoacoustic stimulation of neurons with an unprecedented spatial resolution of 20 microns, enabling selective activation of single neurons or subcellular structures, s...
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 7 authors...
Abstract Focused ultrasound has attracted great attention in minimally invasive therapeutic and mechanism studies. Frequency below 1 MHz is identified preferable for high-efficiency bio-modulation. However, the poor spatial confinement of several millimeters and large device diameter of ∼25 mm of typical sub-MHz ultrasound technology suffered from the diffraction limit, severely hindering its further applications. To address it, a fiber-based optoacoustic emitter (FOE) is developed, serving as a...
4 CitationsSource
#1Yimin Huang (BU: Boston University)H-Index: 10
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 13 authors...
Neuromodulation is an invaluable approach for study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation. Our PANs strongly absorb light in the near-infrared second window and generate localized acoustic waves. PANs can also be surface-modified to selectively bind onto neurons. PAN-mediated activation of primary neurons in vitro is achieved with ten 3-nanosecond l...
Source
#1Linli ShiH-Index: 1
#2Ying JiangH-Index: 4
Last. Chen YangH-Index: 69
view all 7 authors...
Focused ultrasound has attracted great attention in minimally invasive therapy, gene delivery, brain stimulation, etc. Frequency below 1 MHz has been identified preferable for high-efficacy drug delivery, gene transfection and neurostimulation due to minimized tissue heating and cell fragmentation. However, the poor spatial resolution of several millimeters and the large device diameter of ~25 mm of current sub-MHz ultrasound technology severely hinders its further applications for effective, pr...