Anna Klopot
Karolinska Institutet
Internal medicineDownregulation and upregulationEndocrinologyLipogenesisLiver X receptorChemistryPhospholipidPhosphatidylinositolPhosphatidylethanolamineLipid biosynthesisLipid metabolism
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#1Deolinda Santinha (University of Aveiro)H-Index: 7
#2Anna Klopot (KI: Karolinska Institutet)H-Index: 1
Last. Luisa A. Helguero (University of Aveiro)H-Index: 26
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Abstract Liver X receptor (LXR) agonists have the potential to alleviate obesity related diseases, particularly atherosclerosis. However, LXRs are transcriptional regulators that induce de novo lipogenesis and lipid accumulation in hepatocytes which represents a serious adverse effect. In this work, we sought to characterize the LXR agonist GW3965 effects on fatty acid (FA) and phospholipid (PL) remodelling and the correlation with gene expression in order to better understand the underlying eff...
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