Jiaqi Liang
Fudan University
GeneCancerInternal medicineOncologymicroRNACellKEGGStage (cooking)Tumor microenvironmentLung cancerImmunotherapyLungMEDLINEAdenocarcinomaNomogramCancer researchCarcinogenesisMedicineBiologyImmune systemCancer cell
32Publications
5H-index
61Citations
Publications 34
Newest
#1Xing Jin (Fudan University)
#2Yuansheng Zheng (Fudan University)H-Index: 3
Last. Zhengyang Hu (Fudan University)H-Index: 4
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Objectives null To explore the clinical features, molecular characteristics, and immune landscape of lung adenocarcinoma patients with KEAP1/NFE2L2/CUL3 mutations. null Methods null The multi-omics data from the GDC-TCGA LUAD project of The Cancer Genome Atlas (TCGA) database were downloaded from the Xena browser. The estimate of the immune infiltration was implemented by using the GSVA analysis and CIBERSORT. The status of KEAP1/NFE2L2/CUL3 mutation in 50 LUAD samples of our department was dete...
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#1Zhang H (Fudan University)
#2Shan G (Fudan University)
Last. L. Wang (Fudan University)H-Index: 55
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Background null The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. null Methods null This was a retrospective cohort study of 80 ALK-rearranged lung adenocarcinoma patients who had undergone radical surgery and another 3031 ALK mutation-negative patients were retrospectively review...
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#1Guoshu Bi (Fudan University)H-Index: 3
#2Jiaqi Liang (Fudan University)H-Index: 5
Last. Qun Wang (Fudan University)H-Index: 24
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#1Zhencong Chen (Fudan University)H-Index: 6
#2Mengnan Zhao (Fudan University)H-Index: 8
Last. Cheng Zhan (Fudan University)H-Index: 16
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Abstract null null Background null Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in adults. Tumor microenvironment (TME) has been associated with therapeutic failure and lethal outcomes for patients. However, published reports on the heterogeneity and TME in ESCC are scanty. null null null Methods null Five tumor samples and five corresponding non-malignant samples were subjected to scRNA-seq analysis. Bulk RNA sequencing data were retrieved...
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#1Jiaqi Liang (Fudan University)H-Index: 5
#2Zhengyang Hu (Fudan University)H-Index: 4
Last. Qun Wang (Fudan University)H-Index: 24
view all 4 authors...
1 CitationsSource
#1Yajing Du (Fudan University)H-Index: 2
#2Zhengyang Hu (Fudan University)H-Index: 4
Last. Tiankui Qiao (Fudan University)H-Index: 1
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#1Guoshu Bi (Fudan University)H-Index: 3
#2Yunyi Bian (Fudan University)H-Index: 4
Last. Qun Wang (Fudan University)H-Index: 24
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BACKGROUND Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical metabolic pathways, glycolysis and oxidative phosphorylation (OXPHOS), remains poorly defined. METHODS We developed a "double-score" system to quantify glycolysis and OXPHOS in 9668 patients across 33 tumor types from The Cancer Genome Atlas and classified them into four metaboli...
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#1Junjie Xi (Fudan University)H-Index: 11
#2Jiacheng Yin (Fudan University)H-Index: 5
Last. Qun Wang (Fudan University)H-Index: 24
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Objectives: Our study aimed to validate pathologic findings of ground-glass nodules (GGOs) of different consolidation tumor ratios (CTRs), and to explore whether GGOs could be stratified according to CTR with an increment of 0.25 based on its prognostic role. Methods: We retrospectively evaluated patients with clinical stage IA GGOs who underwent curative resection between 2011 and 2016. The patients were divided into 4 groups according to CTR step by 0.25. Cumulative survival rates were calcula...
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#1Yuansheng Zheng (Fudan University)H-Index: 3
#2Yiwei Huang (Fudan University)H-Index: 8
Last. Qun Wang (Fudan University)H-Index: 24
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Abstract Headings aims To establish a microsatellite instability (MSI) predictive model in pan-cancer and compare the multi-omics characterization of MSI-related molecular features. Materials and methods We established a 15-gene signature for predicting MSI status and performed a systematic assessment of MSI-related molecular features including gene and miRNA expression, DNA methylation, and somatic mutation, in approximately 10,000 patients across 30 cancer types from The Cancer Genome Atlas, G...
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#1Guoshu Bi (Fudan University)H-Index: 3
#2Jiaqi Liang (Fudan University)H-Index: 5
Last. Hong Fan (Fudan University)H-Index: 6
view all 9 authors...
BACKGROUND Tumor invasiveness reflects many biological changes associated with tumorigenesis, progression, metastasis, and drug resistance. Therefore, we performed a systematic assessment of invasiveness-related molecular features across multiple human cancers. MATERIALS AND METHODS Multi-omics data, including gene expression, miRNA, DNA methylation, and somatic mutation, in approximately 10,000 patients across 30 cancer types from The Cancer Genome Atlas, Gene Expression Omnibus, PRECOG, and ou...
1 CitationsSource