Jie Liu
Guangzhou University of Chinese Medicine
AdductElectron transferRadicalInhibitory postsynaptic potentialHigh-performance liquid chromatographyCovalent bondChemistryStructure–activity relationshipTroloxBromideHyperosideEllagitanninAntioxidantGallic acidFerroptosisAstringinGeraniinButeinDimerIsorhapontigeninPiceatannolRhapontigeninCorilaginChalconeLinoleic acidLipid peroxidationABTSProtocatechuic acidQuercetinDPPHResonance effectTandem mass spectrometryElectrospray ionizationChromatographyRedoxCyclohexane conformationStereochemistry
6Publications
3H-index
18Citations
Publications 6
Newest
#1Ban ChenH-Index: 8
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng ChenH-Index: 22
view all 6 authors...
Synthetic arylamines and dietary phytophenolics could inhibit ferroptosis, a recently discovered regulated cell death process. However, no study indicates whether their inhibitory mechanisms are inherently different. Herein, the ferroptosis-inhibitory mechanisms of selected ferrostatin-1 (Fer-1) and two dietary stilbenes (piceatannol and astringin) were compared. Cellular assays suggested that the ferroptosis-inhibitory and electron-transfer potential levels decreased as follows: Fer-1 >> piceat...
Source
#1Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 8
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 7 authors...
The search for safe and effective ferroptosis-inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin-induced ferroptosis in bone marrow-derived mesenchymal stem cells (bmMSCs). To determine the mechanism, geraniin was further analyzed using UV-vis spectra and several colorimetric assays, where its IC50 values were always much lower than that of the Trolox positive cont...
1 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Jie Liu (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Meiling ZhuH-Index: 1
view all 7 authors...
The ellagitannin corilagin and its analogue 1,3,6-tri-O-galloyl-β-d-glucopyranose (TGG) were found to protect bone marrow-derived mesenchymal stem cells (bmMSCs) against erastin-induced ferroptosis...
4 CitationsSource
#1Xiaojian Ouyang (Guangzhou University of Chinese Medicine)H-Index: 5
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 10 authors...
Erastin-treated bone marrow-derived mesenchymal stem cells (bmMSCs) were prepared and used to compare the ferroptosis inhibitory bioactivities of four monostilbenes, including rhapontigenin (1a), isorhapontigenin (1b), piceatannol-3′-O-glucoside (1c), and rhapontin (1d). Their relative levels were 1c ≈ 1b > 1a ≈ 1d in 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid (C11-BODIPY), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and flow ...
3 CitationsSource
#1Jie Liu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 7 authors...
To elucidate the mechanism of anti-ferroptosis and examine structural optimization in natural phenolics, cellular and chemical assays were performed with 2′-hydroxy chalcone butein and dihydroflavone (S)-butin. C11-BODIPY staining and flow cytometric assays suggest that butein more effectively inhibits ferroptosis in erastin-treated bone marrow-derived mesenchymal stem cells than (S)-butin. Butein also exhibited higher antioxidant percentages than (S)-butin in five antioxidant assays: linoleic a...
10 CitationsSource
#1Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 8
#1Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 7 authors...
Background Pyrola decorata H. Andres, is exclusively distributed in China and a source of traditional Chinese herbal medicine Luxiancao for more than 2000 years. Here, we evaluated the antioxidant and cytoprotective effects of P. decorata and its five phenolic components (protocatechuic acid, gallic acid, hyperoside, 2′′-O-galloylhyperin, and quercetin), and discussed their antioxidant chemistry.
6 CitationsSource