Shinnosuke Takenaka
Hiroshima University
Messenger RNADownregulation and upregulationmicroRNAChemistryBleomycinABCA3Western blotLungHuman lungDrugPulmonary fibrosisAlveolar typeCancer researchEpitheliumEpithelial–mesenchymal transitionA549 cell
Publications 3
#1Masashi Kawami (Hiroshima University)H-Index: 7
#2Shinnosuke Takenaka (Hiroshima University)H-Index: 1
Last. Mikihisa Takano (Hiroshima University)H-Index: 33
view all 0 authors...
Abstract null null Several studies using bleomycin (BLM)-induced lung injury rat model revealed that epithelial-mesenchymal transition (EMT) contributes to pulmonary fibrosis. Conversely, microRNAs (miRNAs) are considered as useful markers of various diseases. In the present study, we aimed to characterize the EMT state through focusing on alveolar epithelial cells and identify the miRNAs that can be used as markers to predict pulmonary fibrosis using a BLM-induced lung injury rat model. Intratr...
#1Ryoko YumotoH-Index: 23
#2Ayano YamamotoH-Index: 1
Last. Mikihisa TakanoH-Index: 21
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#1Ayano Yamamoto (Hiroshima University)H-Index: 1
#2Masashi Kawami (Hiroshima University)H-Index: 7
Last. Mikihisa Takano (Hiroshima University)H-Index: 33
view all 6 authors...
PURPOSE. Several anticancer drugs including bleomycin (BLM) and methotrexate (MTX) cause serious lung diseases such as pulmonary fibrosis. Although evidences showing the association of epithelial-mesenchymal transition (EMT) with pulmonary fibrosis are increasing, the mechanism underlying anticancer drug-induced EMT has been poorly understood. On the other hand, miR-34a, a non-coding small RNA, has been highlighted as a key factor to regulate EMT in lung. In this study, we elucidated the role of...
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