Antonella Cellini
Downregulation and upregulationFKBPG protein-coupled receptorTransient receptor potential channelTRPCReceptorStimulationTRPC3BiologyCell biology
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Aim: The role of the Na+/K+-ATPase (NKA) in heart failure associated with myocardial infarction (MI) is poorly understood. The elucidation of its precise function is hampered by the existence of tw...
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#1Sandra BandleonH-Index: 2
#2Patrick P. StrunzH-Index: 1
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The Transient receptor potential (TRP; C-classical; TRPC) channel TRPC3 permeates a cation (Na+/Ca2+) influx that is favoured by the stimulation of Gq protein-coupled receptors (GPCRs). An enhanced TRPC3 activity is related to adverse effects including pathological hypertrophy in chronic cardiac disease states. In the present study we identified FK506 binding protein 52 (FKBP52) as a novel interaction partner of TRPC3 in the heart. FKBP52 was recovered from a cardiac cDNA library by a C-terminal...
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