Bing Zheng
Nanchang University
Downregulation and upregulationChemokineKEGGMolecular biologyCD8ReceptorTight junctionMucinTumor necrosis factor alphaKinaseChemistryApoptosisCaco-2ImmunologyAutophagyColitisGoblet cellOccludinT cellEpidermal growth factorBacteroidesPathogenic bacteriaDiamine oxidaseCordycepsLactobacillusBifidobacteriumUlcerative colitisATG5Intestinal epitheliumClostridiumSecretionGut floraMAPK/ERK pathwaySignal transductionRAR-related orphan receptor gammaProtein kinase BMyosin light-chain kinasePI3K/AKT/mTOR pathwayBiologyImmune systemMicrobiologyCell biology
5Publications
3H-index
33Citations
Publications 5
Newest
#1Yudan Wang (NCU: Nanchang University)H-Index: 2
#2Xiaomeng Ding (NCU: Nanchang University)H-Index: 3
Last. Qiang Yu (NCU: Nanchang University)H-Index: 21
view all 9 authors...
Abstract The previous research has indicated that Ganoderma atrum polysaccharide (PSG-1) indirectly affects the immune function of dendritic cells (DCs) in intestinal-like Caco-2/DCs co-culture model, in which NF-κB and MAPK pathway play an essential role. To explore the interaction of Caco-2 in the interaction between the intestinal epithelium and its internal immune cells, the intestinal-like Caco-2/DCs co-culture model was developed. All transcripts of Caco-2 treated with or without PSG-1 wer...
1 CitationsSource
#1Bing ZhengH-Index: 3
#2Mengxi YingH-Index: 3
Last. Qiang YuH-Index: 21
view all 9 authors...
Polysaccharides are one of the main active substances in Ganoderma atrum (G. atrum). The purpose of this study was to explore the protective effect of a G. atrum polysaccharide (PSG-1) on DSS-induced colitis and the underlying mechanism. The results showed that PSG-1 could maintain the integrity of the intestinal structure by promoting the expression of goblet cells and levels of tight junction proteins in the colon of DSS-induced colitis mice. Furthermore, PSG-1 relieved the inhibition of Bcl-2...
2 CitationsSource
#1Mengxi Ying (NCU: Nanchang University)H-Index: 3
#2Qiang Yu (NCU: Nanchang University)H-Index: 21
Last. Mingyong Xie (Jiangxi Normal University)H-Index: 71
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Abstract The present study aimed to investigate the protective effect of cultured Cordyceps sinensis polysaccharides (CSP) on cyclophosphamide (Cy)-induced intestinal mucosal immunosuppression and microbial dysbiosis in mice. Results showed that CSP stimulated cytokines secretion (IL-12, IFN-γ, IL-4, IL-13, IL-6, IL-17, IL-10, TGF-β3, TNF-α, IL-2, IL-21) and transcription factors production (T-bet, GATA-3, RORγt, Foxp3). TLRs (TLR-2, TLR-4, TLR-6) and NF-κB pathway key proteins (p-IκB-α, NF-κB p...
21 CitationsSource
#1Mengxi Ying (NCU: Nanchang University)H-Index: 3
#2Bing Zheng (NCU: Nanchang University)H-Index: 3
Last. Mingyong Xie (Jiangxi Normal University)H-Index: 71
view all 10 authors...
Abstract The aim of this study was to investigate the protective effect and underlying mechanisms of Ganoderma atrum polysaccharide (PSG-1) on cyclophosphamide (Cy)-induced intestinal mucosal dysfunction in mice. Results showed that PSG-1 promoted the formation of IgA-secreting cells, modulated sIgA, IgE, IgG, IgM secretion, and improved TLR-2, TLR-4, TLR-6 mRNA levels while these factors were suppressed after Cy treatment. CD4+ and CD8+ T cell numbers were also elevated by PSG-1. Cytokines incl...
16 CitationsSource
#1Mengxi Ying (NCU: Nanchang University)H-Index: 3
#2Qiang Yu (NCU: Nanchang University)H-Index: 21
Last. Mingyong Xie (NCU: Nanchang University)H-Index: 71
view all 9 authors...
Abstract Intestine is not only the largest digestive and absorbing organ, but also an important defensive barrier of the body. Maintaining healthy intestinal barrier is a prerequisite for intestinal function. In this study, polysaccharides from the cultured Cordyceps sinensis (CSP) were orally given to cyclophosphamide (Cy)-treated mice to investigate its protective effect on intestinal barrier injury. Results showed that CSP had positive effects on intestinal morphology, including restoring vil...
9 CitationsSource