Advait B. Shetty
University of Tennessee Health Science Center
CancerDownregulation and upregulationChemokineInnate immune systemInternalizationSurgeryVimentinCytotoxic T cellIntensive care medicineChemistryIn vitroImmunologyImmunohistochemistryAsthmaPaclitaxelDry-powder inhalerPancreatic tumorPancaMetastasisDrug deliveryFerrichromeDrugPancreatic cancerGemcitabineLeptospiraPectinSpleenTannic acidPopulationDelivery systemPulmonary diseaseElderly peopleRelated factorsLipid metabolismSecretionCancer researchFlow cytometryBiochemistryMedicineAerosolizationBiologyImmune systemCancer cell
6Publications
3H-index
16Citations
Publications 6
Newest
#1Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Suman Kundu (UTHSC: University of Tennessee Health Science Center)
Last. Maria Gomes-Solecki (UTHSC: University of Tennessee Health Science Center)H-Index: 18
view all 0 authors...
The exact global impact of leptospirosis is unknown due to inadequate surveillance systems in place in most low-income countries. In this study, we analyzed the differences in mouse inflammatory signatures involved in pathogenic versus non-pathogenic Leptospira recognition at 24h and 72h post infection. Injection of C3H-HeJ mice with non-pathogenic L. biflexa increased circulation of a few chemokines (5/21, 24%) without secretion of cytokines in blood that resulted in engagement of resident macr...
Source
#1Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 7 authors...
Pancreatic cancer (PanCa) is a highly lethal disease with a poor 5 year survival rate, less than 7%. It has a dismal prognosis, and more than 50% of cases are detected at an advanced and metastatic stage. Gemcitabine (GEM) is a gold standard chemotherapy used for PanCa treatment. However, GEM-acquired resistance in cancer cells is considered as a major setback for its continued clinical implementation. This phenomenon is evidently linked to de novo lipid synthesis. PanCa cells rely on de novo li...
Source
#1Sumeet S. Chauhan (University of Texas at Austin)H-Index: 2
#2Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 3
view all 5 authors...
Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes b...
3 CitationsSource
#1Andrew E. Massey (UT: University of Tennessee)H-Index: 5
#2Mohammed Sikander (UT: University of Tennessee)H-Index: 7
Last. Subhash C. Chauhan (UT: University of Tennessee)H-Index: 49
view all 13 authors...
Abstract Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they prevent appropriate uptake of therapeutic payloads. Thus, our objective is to develop a next-generation nanoparticle system for treating PanCa. We generated a multi-layered Pluronic F127 and polyvinyl alcohol stabilized and poly-L-lysine coated paclitaxel loaded poly(lactic-co-glycolic acid) nanoparticle formulation (PPNPs). This formu...
4 CitationsSource
#1Mehdi Chaib (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Bilal Bin Hafeez (UTHSC: University of Tennessee Health Science Center)H-Index: 29
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 13 authors...
Background : Pancreatic cancer (PanCa) is one of the most lethal malignancy with a very poor survival rate in patients due to inadequate treatment options. Accumulating evidences suggest that tumor associated macrophages (TAMs) and reduce infiltration of CD8+ T-cell population provide tumor suppressive environment leading to advanced growth and metastasis of PanCa. Thus, targeting TAMs and enhancing infiltration of CD8+ T - cells to the tumor site by non-toxic agents could be an effective therap...
Source
The dry powder inhaler (DPI) has become widely known as a very attractive platform for drug delivery. DPIs are being used for the treatment of asthma and chronic obstructive pulmonary disease by many patients. There are over 20 devices presently in the DPI market. DPIs are preferred over nebulizers and pressurized metered dose inhalers. However, some of the challenges of DPI are dependence on inspiratory flow (unsuitable for young children, elderly people), systemic absorption due to deposition ...
3 CitationsSource