Martin Gotthardt
Radboud University Nijmegen Medical Centre
RadiologyEndocrinologySurgeryPathologyReceptorChemistryIn vivoPositron emission tomographyBeta cellPancreasNeuroendocrine tumorsScintigraphyDOTAInsulinomaKidneyOctreotideNuclear medicineRadionuclide therapyChromatographyMedicine
Publications 31
#1Maarten Brom (Radboud University Nijmegen Medical Centre)H-Index: 15
#2Gerben M. Franssen (Radboud University Nijmegen Medical Centre)H-Index: 21
Last. Otto C. Boerman (Radboud University Nijmegen Medical Centre)H-Index: 60
view all 5 authors...
Background Ga-labeled radiotracers are increasingly used for PET imaging. During the labeling procedure, formation of 68Ga-colloid may occur. Upon i.v. injection, 68Ga-colloid will accumulate rapidly in the liver, spleen, and bone marrow, resulting in reduced target-to-background ratios. In this study, we applied a thin layer chromatography (TLC) method to measure colloid content and we studied the effect of the purification method on the in vivo characteristics of 68Ga-labeled DOTA-exendin-3. D...
6 CitationsSource
#1Aglaia KyrilliH-Index: 1
Last. Miriam Cnop (ULB: Université libre de Bruxelles)H-Index: 49
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ABSTRACT Objective: Insulinoma is the most frequent cause of hyperinsulinemic hypoglycemia in adults, but its preoperative localization may be challenging. Methods: We report on a patient with a remarkably long history of persistent hypoglycemia due to an insulinoma, which was finally localized after 18 years using glucagon-like peptide-1 receptor (GLP-1R) imaging. Results: The patient was admitted in 1995 for hypoglycemia. A fasting test documented inadequate insulin suppression. She had given ...
1 CitationsSource
#1Iris Mathijs (Vrije Universiteit Brussel)H-Index: 5
#2Catarina Xavier (Vrije Universiteit Brussel)H-Index: 21
Last. Luc Bouwens (Vrije Universiteit Brussel)H-Index: 52
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Purpose In order to evaluate future β cell tracers in vivo, we aimed to develop a standardized in vivo method allowing semiquantitative measurement of a prospective β cell tracer within the pancreas.
13 CitationsSource
#1Kirsi Mikkola (UTU: University of Turku)H-Index: 7
#2Cheng-Bin Yim (UTU: University of Turku)H-Index: 10
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 69
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Purpose Glucagon-like peptide-1 receptor (GLP-1R) is a molecular target for imaging of pancreatic beta cells. We compared the ability of [Nle14,Lys40(Ahx-NODAGA-64Cu)NH2]-exendin-4 ([64Cu]NODAGA-exendin-4) and [Nle14,Lys40(Ahx-NODAGA-68Ga)NH2]-exendin-4 ([68Ga]NODAGA-exendin-4) to detect native pancreatic islets in rodents.
52 CitationsSource
#1Maarten Brom (Radboud University Nijmegen Medical Centre)H-Index: 15
#2Otto C. Boerman (Radboud University Nijmegen Medical Centre)H-Index: 33
Last. Wim J.G. Oyen (Radboud University Nijmegen Medical Centre)H-Index: 84
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Radiolabeled somatostatin analogues are routinely used for the detection of neuroendocrine tumors (NETs), exploiting the expression of somatostatin-receptor subtypes on the cell membrane. Because of the heterogeneity of the origin of these tumors, the performance of radiolabeled somatostatin analogues in certain types of NETs is limited due to the low incidence or low levels of receptor expression. In this review, the most recent developments and in vitro and in vivo characterization of these ra...
#1Lutz S. FreudenbergH-Index: 34
#2Dirk HellwigH-Index: 32
Last. Martin Gotthardt (Radboud University Nijmegen Medical Centre)H-Index: 14
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In Germany the duration of training in the field of nuclear medicine is 5 years, of which 1 year must be spent in clinical inpatient patient care, and another 6 months of training in another field is possible. It is also permissible to work for up to a year in a radiology department. In contrast, to get credit for the training in nuclear medicine in other fields such as radiology is essentially impossible or there is a very strict time limit. The reason can be found in the differences within the...
5 CitationsSource
#1Floor C. J. van de Watering (Radboud University Nijmegen)H-Index: 5
#2Peter Laverman (Radboud University Nijmegen Medical Centre)H-Index: 37
Last. Jeroen J.J.P. van den Beucken (Radboud University Nijmegen)H-Index: 34
view all 8 authors...
Calcium phosphate cements (CPCs) including poly(D,L-lactic-co-glycolic) acid (PLGA) microparticles are promising candidates for bone regenerative applications. Previous studies with CPC/PLGA demonstrated that the material is non-toxic, biocompatible and osteoconductive. However, the outcome of these studies was based on healthy individuals and consequently does not provide information on bone substitute material performance in a compromised situation, such as osteoporosis. Therefore, this study ...
8 CitationsSource
#1K. Freriks (Radboud University Nijmegen Medical Centre)H-Index: 8
#2Theo C. J. Sas (Radboud University Nijmegen Medical Centre)H-Index: 9
Last. Henri J L M Timmers (Radboud University Nijmegen Medical Centre)H-Index: 40
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Objective: Short stature is a prominent feature of Turner syndrome (TS), which is partially overcome by GH treatment. We have previously reported the results of a trial on the effect of oxandrolone (Ox) in girls with TS. Ox in a dose of 0.03 mg/kg per day (Ox 0.03) significantly increased adult height gain, whereas Ox mg/kg per day (0.06) did not, at the cost of deceleration of breast development and mild virilization. The aim of this follow-up study in adult participants of the pediatric trial ...
17 CitationsSource
#1Gabie M. de Jong (Radboud University Nijmegen Medical Centre)H-Index: 4
#2Thijs Hendriks (Radboud University Nijmegen Medical Centre)H-Index: 32
Last. Otto C. Boerman (Radboud University Nijmegen Medical Centre)H-Index: 33
view all 9 authors...
During the treatment of colorectal liver metastases, evaluation of treatment efficacy is of the utmost importance for decision making. The aim of the present study was to explore the ability of preclinical imaging modalities to detect experimental liver metastases. Nine male Wag/Rij rats underwent a laparotomy with intraportal injection of CC531 tumor cells. On days 7, 10, and 14 after tumor induction, sequential positron emission tomography (PET), computed tomography (CT), and magnetic resonanc...
2 CitationsSource
#1Maarten Brom (Radboud University Nijmegen Medical Centre)H-Index: 15
#2Lieke Joosten (Radboud University Nijmegen Medical Centre)H-Index: 15
Last. Otto C. Boerman (Radboud University Nijmegen Medical Centre)H-Index: 33
view all 5 authors...
Internalizing agonists are usually selected for peptide receptor targeting. There is increasing evidence that non-internalizing receptor antagonists can be used for this purpose. We investigated whether the glucagon-like peptide-1 receptor (GLP-1R) antagonist exendin(9-39) can be used for in vivo targeting of GLP-1R expressing tumours and compared the in vitro and in vivo characteristics with the GLP-1R agonists exendin-3 and exendin-4. The binding and internalization kinetics of labelled [Lys(4...
35 CitationsSource