Yun Yong Park
University of Ulsan
Messenger RNATransforming growth factorCancerInternal medicinePhenotypeFunction (biology)OncologyInsulin-like growth factor 1 receptorGene expressionTranscriptomeRegulation of gene expressionVEGF receptorsSolute carrier familyHippo signaling pathwaygenomic DNASuppressorStage (cooking)KinaseChemistryImmunologyHazard ratioNucleic acidMST1Head and neck squamous-cell carcinomaCarcinomaBiocompositeHepatocellular carcinomaTumor suppressor geneSTAT3FascinDiseaseLiquid biopsyGrowth inhibitionMicrosatellite instabilitySnailCetuximabPancreatic cancerYAP1OncogeneConfusionCirculating Cell-Free DNATOR Serine-Threonine Kinasesß1 integrinRNA-binding proteinMutationCancer researchRegretAmino acidColorectal cancerBreast cancerGastrointestinal cancerBiochemistryCarcinogenesisLysisBioinformaticsCell growthSignal transductionClinical significanceRNAMedicineEpithelial–mesenchymal transitionCell cultureEstrogen receptorPI3K/AKT/mTOR pathwayBiologyCell biologyCancer cellmTORC1
Publications 9
#1Bonhan Koo (UOU: University of Ulsan)H-Index: 10
#2Eunsung Jun (UOU: University of Ulsan)H-Index: 10
Last. Yong Shin (UOU: University of Ulsan)H-Index: 23
view all 8 authors...
Cell-free nucleic acids (cfNAs) in liquid biopsy samples are emerging as important biomarkers for cancer diagnosis and monitoring, and for predicting treatment outcomes. Many cfNA isolation methods have been developed recently. However, most of these techniques are time-consuming, complex, require large equipment, and yield low-purity cfNAs because the genetic background of normal cells is amplified during cell lysis, which limits their clinical application. Here, we report a rapid and simple cf...
2 CitationsSource
#1Seong-Jin Kim (UOU: University of Ulsan)H-Index: 2
#2Jin-Sung Ju (UOU: University of Ulsan)H-Index: 1
Last. Seong-il Eyun (CAU: Chung-Ang University)H-Index: 11
view all 16 authors...
Breast cancer (BC) is one of the most common cancers in women. TNBC (Triple-negative breast cancer) has limited treatment options and still lacks viable molecular targets, leading to poor outcomes. Recently, RNA-binding proteins (RBPs) have been shown to play crucial roles in human cancers, including BC, by modulating a number of oncogenic phenotypes. This suggests that RBPs represent potential molecular targets for BC therapy. Methods: We employed genomic data to identify RBPs specifically expr...
7 CitationsSource
#1M. H. Kang (Ulsan College)H-Index: 2
#2Kang Jin Jeong (University of Texas MD Anderson Cancer Center)H-Index: 29
Last. Yun Yong Park (UOU: University of Ulsan)H-Index: 5
view all 11 authors...
The original version of this article contained an error in Fig. 2e. In Fig. 2e, the sixth colony image of T47D cells treated with shMSI2 was inadvertently replaced with a duplicate of the seventh colony image. However, the conclusions reported in the paper are not affected by figure replacement. The authors regret that these errors were made and apologize for the confusion and inconvenience. The correct version of this figure panel appears in the Author Correction associated with this Article.
2 CitationsSource
#1Bo Young Jeong (Konyang University)H-Index: 6
#2Kyung Hwa Cho (Konyang University)H-Index: 9
Last. Hoi Young Lee (Konyang University)H-Index: 36
view all 10 authors...
After online publication of this article, the authors noticed an error in the Figure 4c and Figure 5c section.
2 CitationsSource
#1Sang Cheul Oh (KU: Korea University)H-Index: 4
#2Bo Hwa Sohn (University of Texas MD Anderson Cancer Center)H-Index: 20
Last. Ju Seog Lee (University of Texas MD Anderson Cancer Center)H-Index: 62
view all 38 authors...
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival...
84 CitationsSource
#1Bo Hwa Sohn (University of Texas MD Anderson Cancer Center)H-Index: 20
#2Jae-Jun Shim (Kyung Hee University)H-Index: 18
Last. Ju Seog Lee (Kyung Hee University)H-Index: 62
view all 24 authors...
Purpose: The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinical relevance of Hippo pathway inactivation in HCC. Experimental Design: We analyzed gene expression data from Mst1/2−/− and Sav1−/− mice and identified a 610-gene expression signature reflecting Hippo pathway inactivation in the liver [silence of Hippo (SOH) signature...
61 CitationsSource
#1Yun Yong Park (UOU: University of Ulsan)H-Index: 21
#2Bo Hwa Sohn (University of Texas at Austin)H-Index: 4
Last. Gordon B. Mills (University of Texas at Austin)H-Index: 201
view all 22 authors...
Metabolic activation is a common feature of many cancer cells and is frequently associated with the clinical outcomes of various cancers, including hepatocellular carcinoma. Thus, aberrantly activated metabolic pathways in cancer cells are attractive targets for cancer therapy. Yes-associated protein 1 (YAP1) and transcriptional coactivator with PDZ-binding motif (TAZ) are oncogenic downstream effectors of the Hippo tumor suppressor pathway, which is frequently inactivated in many cancers. Our s...
72 CitationsSource
Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-β1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4
19 CitationsSource
#1Keun Wook Lee (University of Texas MD Anderson Cancer Center)H-Index: 31
#2Sung Sook Lee (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Ju Seog Lee (University of Texas MD Anderson Cancer Center)H-Index: 62
view all 11 authors...
Purpose: Activation of YAP1, a novel oncogene in the Hippo pathway, has been observed in many cancers, including colorectal cancer. We investigated whether activation of YAP1 is significantly associated with prognosis or treatment outcomes in colorectal cancer. Experimental Design: A gene expression signature reflecting YAP1 activation was identified in colorectal cancer cells, and patients with colorectal cancer were stratified into two groups according to this signature: activated YAP1 colorec...
90 CitationsSource