Jun-Lang Zhu
Guangzhou University of Chinese Medicine
Regenerative medicinePhosphorylationCXCR4microRNACellReporter geneAndrologyChemistryProtein kinase CMesenchymal stem cellIn vivoSmall interfering RNAWestern blotROCK2Homing (hematopoietic)Femoral fractureWNT5ACartilageMTT assayStem cellPopulationTransplantationFemur fractureChondrogenesisCa2+/calmodulin-dependent protein kinaseTransfectionSignal transductionMedicineMyosin light-chain kinaseBone healingBiologyCell biology
5Publications
3H-index
8Citations
Publications 4
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#1Jun-Lang Zhu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Wang Bin (Guangzhou University of Chinese Medicine)H-Index: 4
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Abstract Background Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only a small number of implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration of MSCs in injured tissue. Methods The migration and osteogenesis of MSCs were assessed by transwell assay and Alizarin Red S staining. Levels of gene and protein expressio...
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#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
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Abstract Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homing is extremely limited. Thus, it has become extremely necessary to develop an agent or a method, which can be us...
2 CitationsSource
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Wang-Yang Li (Hunan University)H-Index: 1
Last. Wang Bin (GU: Guangzhou University)H-Index: 4
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ABSTRACT MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further explorat...
2 CitationsSource
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 1
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Yiwen Luo (Guangzhou University of Chinese Medicine)H-Index: 5
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: Bone fractures are very common, and above 5% of the fractures are impaired, leading to nonunions and severe disablilities. The traditional Chinese medicine Bushen Huoxue decoction (BHD) has been used to treat fracture in China. Our previous report has found that BHD promotes migration of rat mesenchymal stem cells (rMSCs) by activating Wnt5a signaling pathway. However, whether and how miRNAs are involved in modulating rMSCs migration induced by BHD has not been explored. In the present study, ...
2 CitationsSource