Sophie E. Upson
Hull York Medical School
Matrix metalloproteinaseDownregulation and upregulationExtracellular matrixTransferrinDirect reduced ironOxidative stressInflammationWound healingCell biology
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#1Holly N. Wilkinson (Hull York Medical School)H-Index: 8
#2Sophie E. Upson (Hull York Medical School)H-Index: 1
Last. Matthew J. Hardman (Hull York Medical School)H-Index: 34
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Iron is crucial for maintaining normal bodily function with well-documented roles in erythropoiesis, hemostasis, and inflammation. Despite this, little is known about the temporal regulation of iron during wound healing, or how iron contributes to wound biology and pathology. In this study, we profiled tissue iron levels across a healing time-course, identifying iron accumulation during late-stage repair. Diabetic murine wounds displayed significantly reduced iron levels, delayed extracellular m...
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